"Valsartan": umarnin don amfani. Medicine "Valsartan" - analogues da kuma sake dubawa

Da miyagun ƙwayoyi ne ake kira "Valsartan" umurci manual bayyana a matsayin hade wajen, kunshe a pharmacological kungiyoyin na gefe vasodilators irin. A amfani da wannan magani yana da wani pronounced hawan jinni sakamako a kan haƙuri. Har ila yau, wannan magani yana da wani zabe antagonistic sakamako a kan AT ₁ rabe da suke da alhakin aiwatar da tsari na angiotensin II. Bugu da kari, halayyar diuretic effects iya yi a kan jikin mutum shi ne a hada da kayan aiki, kamar yadda "Valsartan". Analogs wannan shiri - kwantena "Diovan" "Exforge" "Tantordio" da "Valsakor" - da irin wannan Properties.

Features na pharmacological mataki

Amma ga fasali na pharmacological mataki na antihypertensive jamiái, shi ne, yavlyas takamaiman antagonist ake kira angiotensin II tsoka mai amsa sigina, yadda ya kamata tarewa da AT ₁ rabe kuma qara jini taro na angiotensin II. A daidai wannan magani "Valsartan" (umarnin don yin amfani da bayyana abun da ke ciki) bai hana angiotensin-tana mayar enzyme. Har ila yau, shi ba ya da wani agonist aiki tare da girmamawa ga AT ₁ -receptors. Daga cikin abubuwan, da asali "Valsartan" ba toshe ion tashoshi da kuma rabe da sauran hormones da suke da muhimmanci ga al'ada tsari na zuciya da jijiyoyin jini tsarin. Bugu da kari, da miyagun ƙwayoyi ba shi da wani sakamako a kan matakin tireoglobulinpa, uric acid, total cholesterol, da jini glucose.

Pharmacokinetics

Idan muka magana game da pharmacokinetics na anti-hawan jinni jamiái, kamar yadda wani magani domin "Valsartan", sa'an nan, kamar yadda mai mulkin, shi ne sosai hanzari tunawa daga cikin gastrointestinal fili bayan baka gwamnati, ko da yake mataki na sha dogara a kan mutum bambance-bambance.

A wannan antihypertensive sakamako yawanci fara faruwa bayan da ɗari - ɗari da ashirin da minti bayan guda dosing da miyagun ƙwayoyi, da kuma iyakar warkewa sakamako aka samu a kan talakawan for hudu - shida hours. A cikakkar bioavailability na wannan magani ne kawai a kan 22%. Bi da bi, dauri ga jini sunadaran (yafi albumin) ne 94-98%. A jini yarda da miyagun ƙwayoyi "Valsartan", wanda tsari yana da tasiri kai tsaye a kan shi, shi ne game da 2 L / h. An nuna antihypertensive wakili, yafi a cikin faeces (game da 70%) kuma, zuwa yawa karami har da fitsari. A manufacturer kuma jaddada cewa a yanayin saukan toshewa da bile ducts ko biliary cirrhosis, wannan magani AUC ƙaruwa a talakawan cikin rabin. A musayar da amfani da kwayoyi na wani canje-canje a cikin pharmacokinetic Properties da sigogi kiyaye.

Description da miyagun ƙwayoyi

Samar antihypertensive miyagun ƙwayoyi "Valsartan" (umarnin don yin amfani da abin da ake bukata ne kunshe a kowane fakitin) a cikin nau'i na alluna, film-mai rufi, da kuma a cikin wani nau'i na fararen foda. Wannan abu ne kusan insoluble a talakawa ruwa da kuma readily mai narkewa a cikin methanol da ethanol. A kwayoyin nauyi na wannan halitta ne game da 430-435. Amma abun da ke ciki na wannan matsakaici-vasodilating, sa'an nan a matsayin babban aiki abubuwa yana dauke ne da angiotensin II tsoka mai amsa sigina irin da wani thiazide diuretic.

Filin magani amfani

Dauki kwaya "Valsartan" umarnin don amfani da yafi bada shawarar a matsayin wani ɓangare na abin da ake kira hade far ga mutanen da suka sha wahala daga matsananciyar zuciya rashin cin nasara ko hauhawar jini.

Bugu da ƙari, wannan zane antihypertensive wakili amfani da su inganta rayuwa mutane tare da wani m tsokar zuciya infarction (ciki har da rikitarwa na ramin zuciya systolic tabarbarewa ko hagu na ramin zuciya kasawa). Marasa lafiya da cututtukan zuciya da suka riƙi gargajiya da kwayoyi, diuretics ma quite sau da yawa gudanar da magani "Valsartan". Analogues na wannan kayan aiki kuma za a iya amfani da duk sama lokuta.

sashi

Ɗauki antihypertensive miyagun ƙwayoyi, likitoci kullum bayar da shawarar daya ko biyu a rana sau tamanin ko arba'in milligrams, bi da bi. A cikin rashi na so warkewa sakamako, da kullum sashi za a iya ƙara. Duk da haka, wannan ya kamata a yi a hankali kuma kawai wajabta ta likita. A kalla kashi na daya da miyagun ƙwayoyi ne da ɗari uku da ashirin da milligrams.

Jerin contraindications ga yin amfani da

Yi amfani da kayan aiki-vasodilator masana bayar da shawarar karfi cewa idan akwai wani mutum daga mutum hypersensitivity wa wani daga da aka gyara. Lokacin shigar rashin lafiyan halayen analogously kamata dena shan Allunan "Valsartan". The asali miyagun ƙwayoyi ya kamata kuma, ba za a dauka da marasa lafiya da suke ba su isa da shekaru goma sha takwas. A karshen ne saboda gaskiyar cewa da aminci daga cikin yin amfani da antihypertensive kwayoyi a irin haka ba cikakken gane.

Yi amfani da lokacin daukar ciki

Kuma an wajabta, da miyagun ƙwayoyi "Valsartan" mata wanda ya ɗauko wani yaro, da cikakken contraindicated. Wadannan shirya likita nazarin ya nuna wani fairly high hadarin illa na antihypertensive jamiái a kan tayin. Duk da haka, idan akwai mai tsanani rai-barazanar cuta a cikin wanda ba shi yiwuwa a yi amfani da sauran, mafi aminci magunguna, ko suna kasa tasiri, aikace-aikace na miyagun ƙwayoyi-vasodilator. Dabam ya kamata a ce game da inadmissibility na yin amfani da kayan aiki yayin da ciyar da jariri da nono.

Zai yiwu gefen halayen

Da nada irin wannan antihypertensive miyagun ƙwayoyi, a matsayin "Valsartan" zai iya sa bayyanar da wani m tsanani ciwon kai, juwa ko jiri, tari da kuma rauni. Bugu da kari, akwai sau da yawa tashin zuciya, zawo, hyperkalemia, syncope, da kuma rashin barci. Ciki zafi, vertigo, neutropenia, thrombocytopenia, arthralgia, ciwon baya, myalgia, gajiya, kuma kumburi na iya faruwa a sakamakon irin wannan Drug Administration "Valsartan". Reviews da marasa lafiya baya amfani da shi, kuma nuna hadarin for pharyngitis, rhinitis, sinusitis, da dama kwayar cututtuka da kuma cututtuka da shafi na sama na numfashi sassan. Bugu da kari, mutane da yawa sun lura hyperbilirubinemia, rage hematocrit, hypercreatininemia, karuwa a cikin jini urea nitrogen da abun ciki da kuma raguwa a cikin haemoglobin. Bugu da kari, ya kamata ka ko da yaushe tuna cewa lokaci daya liyafar na nufin-vasodilator "Valsartan" da kuma magunguna daga cikin rukuni na potassium-sunã rãyar da diuretics zai iya sa hyperkalemia ci gaba. A cikin hali na miyagun ƙwayoyi yawan abin sama na iya faruwa yanayi kamar bradycardia, hypotension ko tachycardia.

Basic sauna

A ƙarshe, dole ne a ce cewa wajibi ne tare da matsananci hankali da kuma kawai a karkashin tsauraran likita dubawa sanya liyafar da antihypertensive wakili a cikin marasa lafiya da sodium kasawa, mai tsanani take hakkin da koda, dangantakar stenosis na da ake kira koda jijiya ko wani alama raguwa a zagawa da jini girma. Wannan shi ne saboda da farko zuwa high-hadarin marasa lafiya da jijiya hypotension. Bugu da kari, ya kamata ka biya na musamman da hankali ga mutanen da fama da biliary cirrhosis ko mai tsanani cuta na hanta. Marasa lafiya tare da koda jijiya stenosis bukatar m monitoring na yawa na urea nitrogen da magani creatinine. Har ila yau, musamman da hankali ga kanta bukatar marasa lafiya da toshewa na biliary fili, samun potassium-sunã rãyar da diuretics, musamman kalisodergaszczye potassium kari ko kwayoyi. A karshe, matsananci hankali dole ne a yi amfani da antihypertensive miyagun ƙwayoyi "Valsartan" mutane suke fama da yin alaka da tuki na wani motocin, da waɗanda wanda sana'a ne kai tsaye interfaced da wani babban taro na hankali.