List of antiarrhythmic kwayoyi da kuma su rarrabuwa

Kusan dukan marasa lafiya samu likitan zuciyar ko ta wani hanya tare da daban-daban na arrhythmias. A halin yanzu, da Pharmaceutical masana'antu yayi wani m iri-iri antiarrhythmic jamiái. Su rarrabuwa da kuma halaye tattauna a wannan labarin.

hanya na daukan hotuna

Don warware ectopic cardiac arrhythmias, antiarrhythmic jamiái aka sanya. Ginshikai na mataki na irin kwayoyi ne da nufin aiki na tsokar electrophysiological Properties na Kwayoyin:

• Rage gudun da mataki m, game da shi, inda hakan ya aiwatar da zumudi.
• A karu a excitability na myocardium.
• Rage lokaci zumunta tsaurin, sakamakon rage daga cikin tazara, a lokacin da wani matsanancin turu iya fararwa cardiac ƙanƙancewa.
• Elongation tasiri mai tsaurin lokaci, wanda shi ne muhimmin lokacin da tachycardias kuma domin kawar hatsaisai wanda ke faruwa bayan ma kadan lokaci bayan da ganiya raguwa.
• Capacity kudi na zumudi cewa inganta harkokin homogenization da kuma hana sabon abu na sake shigarwa ( «sake shigarwa").
• Hanawa na ectopic automatism jam'iyya cewa an haɗa da tsawo na tsawon diastolic depolarization.
• Kawar da bambance-bambance a cikin kudi na zumudi da Manuniya refractivity.
• Rage cardiac ji na ƙwarai to lantarki sallama da kuma hadarin na ramin zuciya fibrillation.

Nau'in antiarrhythmic kwayoyi

Duk da magunguna a wannan kungiya ya kasu kashi hudu azuzuwan. Bugu da kari, da farko aji da aka raba kara shiga uku subclasses. Wannan rarrabuwa dogara ne a kan irin nisan da miyagun ƙwayoyi sakamako a kan ikon da zuciya Kwayoyin a gudanar da samar da aiwatar da na'urar sakonni. Daban-daban azuzuwan na antiarrhythmic kwayoyi da su hanyoyi na daukan hotuna, don haka a daban-daban na arrhythmias su tasiri zai zama daban-daban.

A farko aji hada da sauri sodium tashar blockers. IA aji ya hada da irin wannan kwayoyi a matsayin "quinidine" "Dizopiramid", "novokainamid", "Giluritmal". By ibn subclass maida hankali ne akan "Piromekain", "tocainide", "Difenin" "Lidocaine", "aprindine", "Trimekain", "Mexiletine." Subclass IC kafa kayayyakin aiki, kamar "Etmozin", "Ritmonorm" ( "Propafenone"), "VFS" "Etatsizin", "Flecainide", "Indekainid", "Bonnekor", "Lorkainid".

Na biyu aji kunshi beta-blockers ( "metoprolol", "nadolol," "alprenolol," "Kordanum", "Propranolol", "acebutolol", "Pindolol", "Trazikor", "Esmolol").

The uku aji hada da potassium tashar blockers "bretylium tosylate", "Amiodarone", "Sotalol".

A karo na hudu aji hada da alli tashar blockers m (msl, "Verapamil").

List of anti-arrhythmic kwayoyi ba ya kawo karshen akwai. Arziki yana kuma cardiac glycosides, potassium chloride, sodium triphosphate, magnesium sulfate.

Magani farko Class

Sodium tashar blockers sauri bayarwa aka tsaya a cikin cell na sodium, wanda ya haddasa retardation na da nassi daga cikin myocardium zumudi zango. Ta hanyar wannan cropped yanayi na m wurare dabam dabam a cikin zuciya na pathological sakonni, da kuma arrhythmia ta ci gaba. Bari mu bincika ƙungiyar antiarrhythmic kwayoyi na zuwa na farko aji.

Magani Class IA

Antiarrhythmic kwayoyi irin nada a extrasystole (na ramin zuciya da kuma supraventricular) da kuma mayar sinus kari a yanayin saukan atrial fibrillation (atrial fibrillation). Bugu da kari, su ana amfani da su hana maimaita harin.

"Procainamide" da "quinidine" - tasiri antiarrhythmic kwayoyi tare da tachycardia. Za mu gaya muku game da su.

"Quinidine"

Wannan magani da ake amfani a yanayin saukan paroxysmal supraventricular tachycardia, kazalika a paroxysms na atrial fibrillation zuwa sinus kari. Mafi sau da yawa, da magani gudanar a cikin nau'i na alluna.

Guba antiarrhythmic kwayoyi da wuya ya faru, amma a lokacin da samun "Quinidine" yiwu illa kamar narkewa kamar disturbances (amai, zawo), da kuma ciwon kai. Bugu da ƙari kuma, da yin amfani da miyagun ƙwayoyi ne iya haifar da wani karu a jini platelet matakan, intracardiac madugu slowing, Munã rage tsokar contractility. A mafi hatsari gefen sakamako - da ci gaban na ramin zuciya tachycardia, musamman tsari, wanda zai iya sa kwatsam mutuwa daga mãsu haƙuri. Wannan shi ne dalilin da ya sa magani "quinidine" ya kamata a za'ayi ne kawai tare da iko da ECG da kuma karkashin kulawa da wani gwani.

A magani ne contraindicated a intraventricular da atrioventricular block, cardiac glycoside maye, thrombocytopenia, hypotension, congestive zuciya rashin cin nasara, ciki.

"Procainamide"

Wannan magani yana da guda alamomi ga yin amfani da matsayin "quinidine". Popular sau da yawa shi ne wajabta ga manufar taimako na paroxysmal atrial fibrillation. Lokacin da igiyar jini allura "novokainamid" yiwu kaifi raguwa a jini don haka wajibi ne ya gabatar da bayani da aka sannu a hankali iyakar.

Daga cikin illa rarrabe tashin zuciya da amai, canje-canje a cikin jini, cuta na juyayi tsarin a cikin nau'i na dizziness, ciwon kai, a rare lokuta, da ruɗewa. Idan kana amfani da miyagun ƙwayoyi akai, zai iya ci gaba lupus-kamar ciwo (serozity, amosanin gabbai, zazzabi), da ake dasu kamuwa da cuta a cikin baka rami, tare da m waraka raunuka da kuma ulcers da kuma zub da jini gumis. Bugu da kari, "novokainamid" iya tsokane wani rashin lafiyan dauki, a cikin wannan yanayin zai zama na farko alamar faru na tsoka rauni a bayar da magani.

Aiwatar da magani da aka haramta a lokacin da atrioventricular block, mai tsanani na koda da zuciya rashin cin nasara, hypotension da cardiogenic buga.

ibn aji

Irin wannan kwayoyi da kadan sakamako a kan sinus kumburi, atrioventricular dangane da atrium, don haka m, a cikin hali na supraventricular arrhythmias. Nada ta data antiarrhythmic kwayoyi tare da arrhythmia, paroxysmal tachycardia, watau, domin lura da na ramin zuciya arrhythmias. Suna kuma amfani da su bi arrhythmias, wanda aka jawo da wani yawan abin sama na cardiac glycosides.

List of antiarrhythmic kwayoyi a cikin wannan aji ne quite m, amma yana nufin "lidocaine" da ake amfani da mafi sau da yawa. Yawanci, an gudanar intravenously idan akwai mai tsanani na ramin zuciya arrhythmias a t. H. A tsokar zuciya infarction.

"Lidocaine" shi ne iya rushe aiki na juyayi tsarin, wanda aka bayyana dizziness, seizures, da matsaloli tare da jawabin da hangen nesa da cuta da sani. Idan muka gabatar da miyagun ƙwayoyi a high allurai, na iya rage da zuciya kudi, rage cardiac contractility. Har ila yau, rashin lafiyan halayen na iya samar da angioedema, urticaria, pruritus.

"Lidocaine" An contraindicated a atrioventricular block, rashin lafiya sinus ciwo. Magani ba a nuna a yanayin saukan tsanani supraventricular arrhythmias saboda ƙãra hadarin atrial fibrillation.

aji IC

Kwayoyi na ga wannan aji, mika intracardiac madugu, musamman a cikin-Purkinje tsarin. Suna da karfi arrhythmogenic Properties, don haka a yanzu da yin amfani yana da iyaka.

List of antiarrhythmic kwayoyi na wannan aji da aka bai sama, amma ana kullum kawai amfani da "Propafenone" ( "Ritmonorm"). An nuna for supraventricular da kuma na ramin zuciya arrhythmias, a Vol. H. karkashin SVC ciwo. Tun da akwai wani hadarin arrhythmogenic effects, da magani dole ne a yi amfani a karkashin likita dubawa.

Bugu da kari ga arrhythmia, wannan magani zai iya sa ci gaban zuciya da kuma gazawar worsening da cardiac contractility. Daga cikin illa za a iya bambanta bayyanar ƙarfe iyawa a bakin, tashin zuciya da kuma amai. Ba a cire irin wannan illar, kamar Heart hangen nesa, canje-canje a cikin jini gwajin, juwa ko jiri, rashin barci, ciki.

Beta-blockers

Lokacin da qara sautin na m juyayi tsarin, misali, a cikin hali na danniya, hauhawar jini, autonomic cuta, ischemia, a cikin jini, akwai da yawa daga catecholamines, ciki har da adrenaline. Wadannan abubuwa aiki a kan beta-adrenergic rabe na myocardium da take kaiwa zuwa cardiac lantarki rashin zaman lafiya da kuma bayyanar arrhythmias.

Beta-blockers hana wuce kima ruri na rabe da shi kare myocardium. Bugu da kari, sun rage excitability na sel da madugu tsarin, wadda take kaiwa zuwa wani m zuciya kidan.

Magunguna da wannan aji suna amfani da magani daga atrial flutter da atrial fibrillation domin yin rigakafi da taimako na supraventricular arrhythmias. Bugu da kari, sun taimaka a shawo kan sinus tachycardia.

Dauke m antiarrhythmic kwayoyi don atrial fibrillation, tare da banda lokuta inda Pathology ne ya sa ta wani wuce haddi na zagawa da catecholamines.

"Metoprolol" da "Inderal" sukan yi amfani domin lura da arrhythmias. Wadannan kwayoyi da illa kamar slowing zuciya rate, rage tsokar contractility, bayyanar atrioventricular block. Wadannan magunguna iya fararwa sanyi extremities da worsening da na gefe jini ya kwarara. Bugu da kari, da kwayoyi shafi cikin juyayi tsarin, haddasa drowsiness, juwa ko jiri, ciki, memory hanawa. suka kuma canja a watsin da jijiyoyi da tsoka, wanda aka bayyana da gajiya da rashin ƙarfi.

Beta-blockers an haramta daga yin amfani a cardiogenic buga, na huhu edema, insulin dogara da ciwon sukari, asma. Har ila yau contraindications protrude atrioventricular block na biyu digiri, sinus bradycardia.

Potassium tashar blockers

Jerin antiarrhythmic kwayoyi a cikin wannan kungiyar ne da nufin retarding lantarki matakai kuma, da ita tarewa potassium tashoshi a cardiac Kwayoyin. Mafi shahara a wannan aji na magani - "Amiodarone" ( "Kordaron"). Daga cikin abubuwan, shi abubuwa a kan M-holino- da adrenergic rabe.

"Kordaron" da ake amfani da magani da kuma rigakafin na ramin zuciya, atrial da supraventricular arrhythmias, zuciya kari disturbances a kan bango na SVC ciwo. A medicament ne ma gudanar a domin su hana rai barazana na ramin zuciya arrhythmias a marasa lafiya tare da m tsokar. Bugu da kari, shi ne amfani don rage zuciya kudi a m atrial fibrillation.

Idan ka yi amfani da kayan aiki na dogon lokaci na iya ci gaba interstitial huhu fibrosis, canji na launin fata (bayyanar da wani m ya dafa). A wasu lokuta, ciwon kai, barci cuta, ƙwaƙwalwar ajiya da kuma hangen nesa. Yanayin aiki "Amiodarone" na iya zama sanadin sinus bradycardia, maƙarƙashiya, tashin zuciya da kuma amai.

Kada rubũta magani a wani na farko bradycardia, QT da tsawaita, take hakkin intracardiac madugu, thyroid cuta, jijiya hypotension, ciki, asma.

Alli tashar blockers jinkirin

Wadannan kwayoyi gudanar da kulle m alli halin yanzu, game da shi, mur da ectopic foci a atria da sinus kumburi automaticity rage. Jerin antiarrhythmic kwayoyi a cikin wannan kungiyar sun hada da "Verapamil," wanda aka sanya domin yin rigakafi da taimako na paroxysmal supraventricular tachycardia, supraventricular arrhythmia far. "Verapamil" shi ne m, a cikin hali na na ramin zuciya arrhythmias.

Side effects hada atrioventricular block, sinus bradycardia, hypotension, da kuma a wasu lokuta - rage contractile ikon da zuciya.

cardiac glycosides

Nau'in antiarrhythmic kwayoyi ba zai zama cikakken ba tare da wani ya ambaci wadannan kudi. Wadannan sun hada da kwayoyi kamar "Tselanid", "Korglikon", "Digitoxin", "Digoxin" da sauransu. Suna amfani da mu mayar sinus kari, supraventricular tachycardia, akan rage na ramin zuciya rate a cikin hali na atrial fibrillation. Lokacin amfani cardiac glycosides da ka saka idanu da yanayin. Ãyõyin Digitalis maye bayyana ta ciki zafi, tashin zuciya da kuma amai, ciwon kai, Heart hangen nesa da kuma wani mafarki, zub da jini daga hanci.

An haramta amfani da wadannan antiarrhythmic kwayoyi a lokacin bradycardia ciwo ERW intracardiac kawancen. Su ba su nada a cikin hali na paroxysmal na ramin zuciya tachycardia.

hade antiarrhythmics

Idan ectopic rhythms a asibiti yi, wasu hade da kwayoyi amfani. Saboda haka, "Quinidine" iya amfani a tare da cardiac glycosides ga zalunta m arrhythmia. Tare da beta-blockers "quinidine" za a iya sanya wa taimako na na ramin zuciya arrhythmias tsaurin zuwa wasu jiyya. A hada da yin amfani da beta-blockers kuma cardiac glycosides ya ba mai kyau da sakamako a cikin na ramin zuciya da kuma supraventricular arrhythmias, kazalika da taimakawa wajen hana kōmōwa na ectopic tachycardia da tachyarrhythmia.