Ga abin da manufa da samfurin da aka gudanar Coombs?

Coombs - wani takamaiman awon gwajin da damar domin sanin antibodies a cikin jini , ko da ja jini cell surface. Wannan hanya damar gane asali rigakafi hemolytic anemia, ciki har da jariri, kazalika don gane hemolytic transfussion halayen. Coombs ne rayayye a yi amfani da na bincike kimiyya da yabanyarta bincike domin sanin ko erythrocyte antigens. Yarda da dukan dokokin da irin wannan bincike ya sa ya yiwu don samun mafi dogara da sakamakon.

Dalilin antiglobulin gwajin

Direct Coombs gwajin zai iya gano anti-erythrocytic antibodies, wanda ake gyarawa a kan erythrocytes. M dauki a lokacin da irin wannan binciken ya nuna wajen raya autoimmune hemolytic anemia. Ya kamata a lura da cewa wani mummunan sakamakon ba ware gaban autoimmune cuta, tun antibodies sau da yawa samu a free form, Ina nufin babu mahaɗi da erythrocytes. A irin haka shi ne bu mai kyau zuwa ga gudanar da wani kai tsaye ba Coombs gwajin, wanda zai ƙayyade m jamiái a magani.

Ta yaya ne analysis?

W Bundled venous jini na haƙuri ne da za'ayi a kan komai a ciki da safe, duk da cewa wani gagarumin abubuwan da tasiri karshe sakamakon wannan gwajin, shi ne ba a saukar. Store abu halatta dauka a 2 zuwa 8 ° C ba fiye da kwana bakwai. Don Manuniya na wannan binciken sun kasance a matsayin daidai kamar yadda zai yiwu, da dukan jini a lokacin farko da sa'o'i biyu a tsĩrar da dakin gwaje-gwaje. Fi dacewa Coombs samfurin ya kamata ya nuna wani mummunan sakamakon, ya nuna babu hemolytic canje-canje a cikin jiki.

Deciphering TOTALS

Coombs ne wajen laborious bincike hanya, wanda na bukatar mai da hankali da kuma m. Lokacin amfani da irin wannan gwajin iya ci karo da wasu matsaloli da cewa suna da dangantaka da ba daidai ba fassarar da karshe sakamakon saboda rauni bayyanuwar tabbatacce halayen. Ya kamata a lura da cewa unreliability analysis - wato tabbatacce Coombs - yana iya zama wani sakamako na kasa aiki wanka erythrocytes lamba tare da m
surface da neutralization aka gyara antiglobulin reagents magani. Wani hasara na wannan hanya ne rashin zaman lafiya da binciken dauka kayan ajiyar wanda yana da wasu siffofin.

A sabili da ƙarya-korau sakamakon zai iya zama fiye da kima girgiza dakatar da erythrocytes a resuspension. Kuskuren da sakamakon iya zama saboda gaban anticomplement antibody impurities wanda ake adsorbed a kan surface a lokacin shiryawa da gwajin erythrocytes, game da shi, samar da bayyanar sakamakon tabbatacce. Idan ka a hankali wanke gwajin samfurori da kuma saka idanu da dauki yanayi, wadannan disadvantages za a iya shafe ta, wanda zai ƙara chances na samun mafi m Manuniya na Coombs gwajin.