"Epoetin Alfa": umurci manual, reviews da analogues

Uncharacteristic matakin na maida hankali na haemoglobin - daya daga cikin cututtuka na anemia. A gaskiya, wannan ba wani ganewar asali, amma kawai alama cewa ne hallmark na da yawa cututtuka. A ci gaba da irin wannan cuta na iya nuna wani primary rauni na jini tsarin.

A stimulator na erythropoiesis, da aka sani a karkashin kasa da kasa wadanda ba na mallakar tajirai sunan kamar yadda "Epoetin Alfa" umarnin don amfani a matsayin high yi sakawa reagent pharmacological Properties ake nufi ga jiyya da kuma rigakafin anemias na daban-daban etiologies. Yadda ya kamata zaba sashi ba kawai taimaka dattako jini bangaren tsarin, amma kuma yana da kyau sakamako a kan zuciya tsoka.

Saki tsari da kuma sinadaran da abun da ke ciki

A magani samfurin ne samuwa a Pharmacy a cikin nau'i na:

• bakararre iya yarwa sirinji tare da saiti kashi (zane azurta ƙarin kariya needles).
• bayani a vials.

Rawar da karin sashi ne ba:

• injectable ruwa.
• chloride dihydrate da sodium hydrogenphosphate.
• polysorbate-80.

A nazarin halittu aiki na dũkiyõyinsu a cikin kwalba na iya zama daban-daban. A mafi yawan lokuta, dubu ko dubu biyu International Raka'a da 0.5 ml na ruwa. Duk da haka, akwai kuma sayar da sauran siffofin reagent, ciki har da "epoetin Alfa" 10,000 inji mai kwakwalwa. / 1 ml.

The inji pharmacological mataki

Halittu da kuma immunological Properties na hada samfurin ne m ga halitta erythropoietin. Saboda haka, magani sosai yadda ya kamata cike da bayyanar cututtuka na anemia, kuma ya gyãra da jini a matsayin wani hali glycoprotein. Dole ne in ce cewa "epoetin Alfa" da farko da nufin kara hematocrit da haemoglobin matakan daidaita. Da "zuciya aiki," kazalika da hali na gyara don inganta jini ya kwarara da kyallen takarda ne kasa pronounced.

rabin lokaci:

• da igiyar jini allura - hudu hours
• lokacin da allura subcutaneously da - game da wata rana.

Matsakaicin maida hankali a reactant a cikin jini za a sa ran bayan 12-18 hours.

pharmacokinetic nuances

Nazarin ya nuna cewa da aka bayyana miyagun ƙwayoyi arna a cikin samuwar antibodies a cikin "dormant" Yanayin, da kuma ta pharmacological muhimmancin a cikin matakai na bargo fibrosis ne kusa da sifili. The gina jiki sulusi da murabba'i medicament "Epoetin Alfa" kunshi game da 165 amino acid (58% na jimlar kwayoyin nauyi), kuma wannan yana nuna a cikin mataki da kuma ingancin da aka gyara tasiri cikin division / bambantawa na progenitor Kwayoyin.

Maimaita igiyar jini gwamnati (a cikin rashi na koda pathologies) ba ya haifar da da jari na aiki abu. yara yan kasa da shekaru 12 da shekaru ne m da tsawaita na T1 / 2 lokaci har zuwa 6 hours.

alamomi ga

"Epoetin Alfa" an shawarar don amfani idan:

• anemia kamu a matsayin cuta na hematopoietic aiki, wanda ke tafiya tare ciwon daji (dauki wuri ya zama maras myeloid marurai).
• da mãsu haƙuri ji da bukatar yau da kullum hemodialysis ko peritoneal dialysis .
• ne mai tambaya na dauke da fitar hadaddun tiyata tare da yin amfani da allogeneic jini.
• da haƙuri da aka kamu da cutar HIV da samun far a kan tushen da zidovudine.
• Zira kwallon bukatar rigakafin.

A mafi kyau duka dosing regimen

Domin shirye-shiryen "Epoetin Alfa", da dabara ga mutum zabin da kullum kashi. Duk da haka, da janar shawarwari na manufacturer da aka iyakance zuwa irin dokokin da kuma matsayin:

• a farkon gyara lokaci hamsin mataki raka'a (Iu) da kilogram jiki nauyi, amma ba fiye da uku injections / infusions da mako.
• in babu a bayyane shift: 75 raka'a / kg a wannan tazara, amma ba a baya fiye da wata daya bayan qaddamarwa magani.
• a cikin kwarai halin da ake ciki: 100-200 U / kg, su bin ce allura jadawalin (mataki karuwa - 25 raka'a / watan).
• tabbatarwa far: kashi gudanar a cikin kudi da yake cikin hematocrit kewayon 30-35 vol. %.

Kamar yadda yi nuna, domin "misali" yawanci dauka guda kudi na 30-100 Iu / kg, wanda mafi yawa ana fitar a karshen dialysis. A mafi kyau duka tsawon na i / v jiko - daya zuwa biyu minti. inji for subcutaneous bayarwa na aiki abubuwa bi wannan dokoki.

Nau'in yiwu illa

A tatsuniyoyinsu atypical kwayoyin ta dauki ga gaban da miyagun ƙwayoyi aka gyara "Epoetin Alfa" umurci manual rahoton da wadannan:

• yiwu ga ganin bayyanar cututtuka musamman zuwa mura ƙwayoyin cuta - tsanani dizziness, ciki, da rauni, da zazzaɓi, mai tsanani hadin gwiwa zafi / tsoka.
• yarda da imbalances na zuciya da jini arteries - mai kaifi karuwa a jini, m hauhawar jini.
• ba wanda zai iya watsi da hadarin thrombocytosis (da cutar, ko da yake yana da wani sakamako ne musamman rare, amma shi ne fraught tare da tsanani da rikitarwa).
• reagent a urinary tsarin ne iya tasiri ta hanyar canza adadin potassium da sinadarin phosphate a cikin jiki (ba su fitar creatinine matakan kara a jini jini).

A fata ne kuma wani lokacin m hangula jawo da gabatarwar "Epoetin Alfa" shirye-shiryen. Umurnai, musamman, yana magana rashes, eczema, angioedema. Kuma abin da ke ban sha'awa: a lokacin da subcutaneous allura kashi mai tsanani ne yafi hakan: a kan talakawan dubu lokuta, lissafin kudi don game da 4 aukuwa (da a / a infusions - 1.6 kawai).

A kan rigakafi da canje-canje da zai sa ya ce abu, ba a dogara da bayanai (lura sai dai cewa a baya aka ambata ikon da miyagun ƙwayoyi a sa samuwar antibodies).

Bisa ga manufacturer contraindications

Bisa ga bayanin da aka bayar a cikin aikin hukuma jagora, "Epoetin Alfa" (analogs kamar "Binokrit" da "Eralfon" a cikin wannan girmamawa kamar yadda kusa da asali) kada a yi amfani idan:

• kamu da uncontrolled hauhawar jini.
• da haƙuri abubuwan hypersensitivity da sinadaran.
• Na farko analysis nuna wani m pathologies jini Lines.
• da haƙuri sha wahala a zuciya (muna magana ne game da 'yan baya).
• akwai dalilin yi imani da cewa rushewa daga al'ada jini ya kwarara a cikin kwakwalwa.

A wasu kalmomin, da farko na far dole ne a wadda ta gabãta daga wani likita jarrabawa.

tsõratar

"Epoetin alpha" (tradename da fasali m halitta iya zama daban-daban - misali, a matsayin mai sauyawa za a iya miƙa analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", da dai sauransu ...) Dole ne a yi amfani da ya karu da taka tsantsan da mutanen da fama da maimaita / kullum cuta na gefe tsokoki. Wannan mulki Gaskiya ne, idan wani tarihi a matsayin mayar da martani na jiki zuwa ci na wasu kwayoyi riga an rubuta aukuwa na convulsive halayen.

Yana ba ya tsoma baki tare da taka tsantsan da kuma for gout. Wasulla farko bukatar sanya a cikin al'amuran da suka shafi hawan jini da kuma abin da ya faru na ciwon kai (antihypertensives - daya daga cikin wadannan likita Hakika gyare-gyare). Duk da haka, shi ne daidai da muhimmanci don kimanta da kuma gaskiya jihar na baƙin ƙarfe Stores (kafin yau da kullum injections). Lokacin dauke da fitar da isassun ayyukan ba sa sanyawa a cikin sharuddan na jini, dabara aka bayyana a pharmacological samfurin da aka tsaya.

Mu tuna cewa dole ne koda gazawar, ciwon daji da kuma cutar HIV ne a kan jerin cututtuka a cikin shakka daga abin da, kan bango na hematocrit taro, akwai wata xabi'a karu a ferritin matakai a jini jini. Don magance imbalances makõma zuwa canzawa far shafe Fe-dauke da reactants.

Samfurori for haemoglobin shi ne bu mai kyau ya dauki 1 lokaci kowace 7 kwanaki. Har ila yau, a lokacin da ƙaddamar da watanni biyu ake bukata na yau da kullum saka idanu na platelet count. Kuma ga 5-10 kwanaki kafin tiyata, a haƙuri ne gudanar magani katin abubuwa da ciwon antithrombotic Properties.

A manufacturer ba sarauta daga abin da aka gyara daga cikin miyagun ƙwayoyi iya shafar wasu iri marurai, don haka kallo na haƙuri kamata ba za a tsaya ko da ta karshen aiki magani lokaci.

Abin da ya yi a idan akwai wani yawan abin sama?

"Epoetin alpha" (ma'ana-da kwayoyi, ba zato ba tsammani, yi a irin wannan hanya) tare da wani yawan abin sama ya aikata bisa ga Algorithms rajista a sinadaran dabara na recombinant erythropoietin Ina nufin tsokani polycythemia hematocrit matakin da oscillations. Saboda da rashin classic antidotes, wasu na musamman da matakan for deactivation da sinadaran ba za'ayi - kawai soke wata ganawa magani.

M bloodletting zartar a lokuta da gaggawa, idan an kan-da iyaka nuna alama na haemoglobin nuna wani real barazana ga rayuwa.

Hulɗarka tare da Magunguna

A gudanar da Multi-mataki hadaddun far ne musamman da muhimmanci a fahimta ka'idojin "pharmacological hali" "Epoetin Alfa" reagent (saki tsari, kamar yadda aka bayyana a sama, za a iya zama daban-daban, amma inji wannan biochemical dauki ba ya canja).

Kamar wancan ne, musamman, a layi daya da gabatarwar jini kayayyakin yana da kyau sakamako a kan inganta kuzarin kawo cikas. Amma dole ne mu tuna cewa dilution da wani bayani na wani ne inadmissible. A miyagun ƙwayoyi ne "ƙungiyar" cyclosporin fraught tare da ragewa taro na karshen (da ganiya volumetric rabo daga cikin allurai da aka kaddara empirically).

comments

Analysis na da ra'ayoyi nuna cewa mafi girma yawan tambayoyi tashi a lokacin da ta je da zabin don warware wannan matsala. Alal misali, 'yan daga cikin marasa lafiya masani a cikin bambance-bambance da suke faruwa tsakanin wannan pharmacological kayayyakin, kamar "epoetin Alfa" da "epoetin beta."

Mene ne bambanci - sauki fahimta, idan muka kula da comments na likitoci. Gaskiyar cewa tsarin model na halitta erythropoietin aka wakilta sarƙa biyu, tare da ake so sakamako a kan jini tsarin da biyu. Masana'antun wannan magani, saboda bambance-bambance a fasahar, ko haduwa alpha-guntu, ko beta.

Amma ga comments a kan shirye-shiryen da kanta, da yawa daga waɗanda suka yi kokarin shi ga kanka, show cewa yana nufin shi ne quite tasiri, da kuma a wasu lokuta na musamman da kuma a duk makawa ga wasu Categories marasa lafiya.