Sodium valproate: girke-girke, da umarnin, saki form, inji na mataki, da dabara

Duk wani rashin lafiya na aiki na tsakiya m tsarin bukatar kusa da hankali. Don magance irin wannan matsaloli ɓullo da taro magani tare da daban-daban ka'idodin mataki a cikin kwakwalwa. Daya daga cikinsu shi ne "sodium valproate".

Babban aka gyara da kuma nau'i na

Babban aiki sashi daga cikin miyagun ƙwayoyi - da sodium gishiri na valproic acid - shi ne mai lafiya crystalline fararen foda da ciwon wani wari. Wannan shi ne a saki nau'i na da miyagun ƙwayoyi "sodium valproate". Formula - S8N15NAO2. Saukake narkewa a cikin barasa da kuma ruwa.

A mabukaci aka miƙa a Allunan, kuma biyu-Layer polyethylene bags. The karami zai yiwu girma a guda kunshin - 0.5 kg. Bugu da ari ASC: 1, 2, 5, 10, 20, 25, 30, 40, 50, 65 kg.

pharmacodynamics

Antiepileptic kwayoyi - babban aiki na da shirye-shiryen "sodium valproate". Ginshikai na aikin dogara ne a kan sa ran karuwa a cikin matakan Gaba (amino acid, shi ne wani muhimmin mai hanawa neurotransmitter a cikin mutane da sauran dabbobi masu shayarwa) a cikin CNS da inhibiting Gaba-transaminase kuma rage reuptake na abu a cikin kwakwalwa nama. A sakamakon wannan tsari, a fili, shi ne don rage excitability da kuma saukin kamuwa da mota yankunan na kwakwalwa ga ci gaban seizures.

Sodium valproate iya samun tranquilizing sakamako a rage tashin hankali, inganta yanayi marasa lafiya, su shafi tunanin mutum yanayin. Bugu da kari, shi nuna wani antiarrhythmic sakamako. Da miyagun ƙwayoyi nuna high dace a rashi seizures (epilepsy alama, daya irin farfadiya kãmun) da kuma na boko psevdoabsansah, amma kusan babu sakamako a kan yanayin marasa lafiya da psychomotor ci gaban seizures.

A fanni na rinjayar da miyagun ƙwayoyi

Babban aikace-aikace na medicament "sodium valproate" umurci manual shirya epilepsy, duka biyu kamar yadda monotherapy kuma a hada magani embodiment. Da miyagun ƙwayoyi da ake amfani a gaban jimlace seizures (polymorphic, manyan da convulsive t. D.), Kuma da m mai da hankali (motor, psychomotor da t. D.). Bugu da kari, da miyagun ƙwayoyi an wajabta, a convulsive cuta ana sau da yawa tare da kwayoyin cututtuka na mutum juyayi tsarin cuta yawanci je hannu da hannu tare da epilepsy a febrile convulsions da kuma juyayi tics a marasa lafiya-yara.

Sodium valproate jagora ya bada shawarar yarda marasa lafiya da manic-depressive bipolar halin yanzu a cikin lokuta inda cutar ne mai tsaurin ga jiyya da lithium da sauran magunguna.

Don amfani da wannan magani?

A cikin irin wannan hadadden kayayyakin kamar yadda anti-farfadiya, akwai ko da yaushe a wasu jerin contraindications zuwa ga amfani. Daya ba zai iya dauka da wakili, wadda ta san hypersensitivity zuwa abu kamar valproic acid (sodium valproate, da kanta da kuma ya hada da ta sodium gishiri). Dalilin da ba amfani ne gaban aikin munanan a marasa lafiya hanta da kuma / ko pancreas. Ya kamata mu ma haskaka a cikin wannan rukuni na cututtuka Hepatitis (duk siffofin - m, na kullum, miyagun ƙwayoyi, da dai sauransu, ciki har da wani tarihi na iyali ..).

Yana ba rubũta wani magani a hemorrhagic diathesis, porphyria (kusan 99% na lokuta da hereditary sabawa bayyana a take hakkin pigment metabolism tare da babban abun ciki a cikin jini da kyallen takarda da porphyrins).

sodium valproate da ciki

Da yin amfani da miyagun ƙwayoyi a farkon trimester ciki ne contraindicated. A karo na biyu da kuma na uku trimester likita zai rubũta magani domin saye da "sodium valproate" sayen magani kawai idan da ana tsammanin amfãni ga uwar wuce hadarin m ga jariri.

Marasa lafiya ya kamata a sanar da cewa valproic acid iya fararwa da ci gaban mai yawan nakasar malformations a tayin. Bugu da kari, wannan abu ne excreted a nono (taro iya isa 10% na adadin dauke a cikin uwa tasa ta jini). Saboda haka, nono-ciyar a lokacin jiyya da magunguna dauke da valproic acid a cikin abun da ke ciki, yana halatta ne kawai a lokuta da matsananci larura.

Kamar yadda a duniya shawarwarin na Ladies suke a cikin haihuwa shekaru, amfani ne na dogara wajen ko hanyoyin da maganin hana haihuwa.

a ke so effects

Ga marasa lafiya bi da tare da magani "sodium valproate" umurci manual ƙunshi bayani game da yiwu gefen sakamakon da daban-daban da kuma tsarin gabobin.

Zai yiwu dauki a kan wani ɓangare na tsakiya m tsarin iya zama wani tremor, canje-canje a cikin yanayi, hali, illa daidaituwa, sleepiness, juwa ko jiri, ciwon kai, irritability, restlessness da kuma sabon abu tashin hankali.

A m dauki Git - asarar ci, dyspepsia, tashin zuciya da amai, zawo, kananan hanji cramps ko ciki yankin. Shi ne nadira ya ji na maƙarƙashiya ko pancreatitis. A mata, da hailar sake zagayowar mai yiwuwa ne. Sau da yawa da wuri ya zama nauyi da hawa da sauka, a daya shugabanci ko wata. Coagulation tsarin iya amsa thrombocytopenia, ta ƙara adadin lokaci da ake bukata domin hana zub da jini. Dermatological yiwu sabawa matsayin alopecia (pathological asarar gashi), rashin lafiyan - wani kurji a kan fata.

sashi regimen

A sashi regimen ga kowane haƙuri shi ne tsananin mutum. "Sodium valproate" wanda siffar rajista - a foda siffan gudanar dangane da jiki nauyi. Harufan sashi na manya da yara yin la'akari fiye da 25 kg ne 10-15 MG da kilogram jiki nauyi (kullum girma). Idan ba ka bayyana su zama wani m events hankali (kowace 3-4 kwana) da sashi za a iya tashe zuwa 200 MG / rana. har sai, har sai wani gagarumin asibiti sakamakon za a iya samu. A talakawan kullum sashi na iya zama har zuwa 30 MG / kg.

Jiyya regimen magunguna - 2-3 sau a rana a lokacin da abinci.

Har ila yau aikata aiki sodium valproate intravenously (halal shiri - 400-800 MG) ko jiko (25 MG / kg na tsawon 24, 36, 48 hours).

Matsakaicin yiwu kashi domin lura da adult marasa lafiya da kuma yara da ciwon jiki nauyi fiye da 25 kg - 50 MG / kg per day. Idan har bisa wani dalili ya zama dole (kashi) karuwa, wani da ake bukata kafun ne wajen saka idanu da taro na valproate a cikin abun da ke ciki na jini jini. Idan wannan kudi na fiye da 200 MG / l - sashi ya kamata a rage.

wuce kima allurai

Idan saboda wasu dalilai akwai haddi na halatta kashi "sodium valproate" (girke-girke a Latin sauki fahimta nisa ba dukan marasa lafiya), akwai jerin unequivocal bayyanar cututtuka. Mafi na kowa halayen ne disturbances na mota daidaituwa da kuma balance, retardation, Myasthenia Gravis (pathologically gajiya), hyporeflexia, nystagmus (involuntary ido hawa da sauka a high mita), miosis (ƙanƙancewa na almajiri), zuciya block, coma.

Jiyya ne da za'ayi a wani asibiti yanayi da kuma na ciki da lavage ne (yadda ya kamata a lokacin da enterally cikin 10-12 hours), don samar da wani osmotic diuresis (manyan girma na fitsari da wani babban taro na osmotic aiki bangaren) da kuma goyon bayan da muhimmanci jikin ayyuka. Good sakamako ba hemodialysis.

Hulda da sauran abubuwa

A wani layi daya aikace-aikace tare da wasu neuroleptics, antidepressants, Mao hanawa, daban-daban benzodiazepine Kalam ethanol da sodium valproate kara hana ruwa guda sakamako a kan ta tsakiya m tsarin. A hada da yin amfani da miyagun ƙwayoyi a hepatotoxic kwayoyi, antiplatelet jamiái, anticoagulants, iya tsokana da karin tasirin wadannan abubuwa.

Layi daya daga haɗuwa da valproic acid da kuma phenobarbital gubar zuwa gudun hijira na karshen daga dauri da jini da sunadarai. Sakamako - ƙara da shi (phenobarbital) yawa a cikin jini.

Kullum, sodium valproate iya shiga cikin hulda da dama magunguna, duk da haka zai yiwu (ko unacceptable) liyafar da ta layi daya tare da sauran kwayoyi da haƙuri kamata a sanar da zalunta likita.

musamman umarnin

Tare da babban sauna magani wajabta wa marasa lafiya fama da cututtuka na hanta da kuma pancreas (ko da ciwon su a cikin tarihin), yara shekaru a karkashin shekaru 3 (iyakar hadarin hepatotoxicity, amma rage-rage tare da shekaru). Ya kamata a haifa tuna cewa yiwuwar samun faru na korau effects daga hanta ya karu a lokacin da hada anticonvulsant far.

Very m zuwa ga kiwon lafiya dole ne marasa lafiya shan "sodium valproate" da kuma ciwon jini dyscrasias. Organic kwakwalwa cuta, munanan a koda aiki, hypoproteinemia - ne ma wani tsanani hadarin dalilai for illa.

A lokacin farko watanni shida na lura da sodium valproate da muhimmanci a ci gaba da saka idanu da jihar na jini coagulation tsarin, hanta, na gefe jini hoto.

Mutane shan wani magunguna anticonvulsant, sodium valproate far kamata a fara a hankali, don kawai su cimma wani tasiri kashi na kimanin 12-14 kwanaki baya. Bayan haka, kawai bukatar hankali soke a baya na samu anticonvulsant kwayoyi. Idan irin wannan shirye-shirye ba amfani kafin a haƙuri, da tasiri kashi na asibiti sakamakon da za a samu a cikin mako guda.

Kan bango na yin amfani da miyagun ƙwayoyi ya kamata a dauka a lokacin da hanya management da kuma aiki, bukata maida hankali da hankali da kuma gudun psychomotor halayen.

Kuma mafi muhimmanci ...

Dalili na applicability na wani antiepileptic miyagun ƙwayoyi (ba da wani togiya da sodium valproate) - sayen magani danganci likita.

Kawai ma'aikacin kiwon lafiya a cikin wani wuri don kimanta duk daga cikin abubuwan da shirya gudanar far tare da da wani magani. Raba Sirri na nufi ne fraught tare da tsanani magunguna sosai, mummunan sakamakon da kiwon lafiya matsayi - har zuwa coma da kuma mutuwa.