Da miyagun ƙwayoyi "Amiodarone": analogues, umarnin, reviews

Zuciya, kamar yadda ka sani, mu main jiki, amma sau da yawa ta kasa. Domin mayar da al'ada aiki amfani da dama kwayoyi. Daya daga cikinsu shi ne "Amiodarone". Analogs ne yafi tsada, kamar yadda ake samar kasashen waje da kuma ba da yaushe tasiri.

A abun da ke ciki na miyagun ƙwayoyi da kuma nau'i na

A medicament "Amiodarone", wanda sake bitar wani iri-iri qunshi a daya hannu na 200 MG na aiki sashi - amiodarone hydrochloride. A shirye-shiryen da aka sanya mafi kamar yadda wani bayani, inda 3 ml ne 5% na aiki sashi.

Karin bangaren hada daya kwamfutar hannu ne: dankalin turawa, sitaci, crystalline microcellulose, lactose, maltodextrin, primelloza, polyvinylpyrrolidone, magnesium stearate.

A Allunan rufe glaze da farin launi da kadan, dabara cream inuwa. Bã su da wani nau'i na Valium da wani facet da Valium. Saboda haka, idan ya cancanta, za su iya sauƙi a kasu kashi biyu daidai sassa.

Drug sayar a kwali kwalaye, inda daya ko biyu blisters da goma Allunan. Da miyagun ƙwayoyi ne ma samar a cikin ƙarau, polymeric da kuma roba kwalabe, wanda da 30 ko 100 Allunan.

A pharmacological inji miyagun ƙwayoyi mataki

Antiarrhythmic da antianginal Properties an halin "Amiodarone" analogues a wasu lokuta za a iya maye gurbin shi. Its anti-arrhythmic mataki dogara ne a kan rage yanzu na potassium ions lokacin hõre membrane Kwayoyin - cardiomyocytes. Ana sa a rage a cikin sinus kumburi wanda Forms bradycardia.

Amfani da miyagun ƙwayoyi "Amiodarone" (kwayoyi) zai iya kara tsawon na tsaurin cardiac madugu inji. Damuarn da watsin da sakandare tafarkin da a marasa lafiya tare da m ciwo na Wolff-Parkinson-White ciwo. Bi da bi, da antianginal miyagun ƙwayoyi sakamako da aka gina a kan rage tsokar oxygen amfani da rage da tasiri a kan jijiya tsokoki. Aka hada da aidin, wanda yake a cikin yin amfani da gwada yawa musanya abun ciki na thyroid hormone, sakamakon a cikin mataki na da tasiri a kan myocardium an rage.

"Amiodarone" yana mai tarawa sakamako, kuma a pronounced sakamako a kan ta aikace-aikace na faruwa ne kawai bayan daya mako na yau da kullum da amfani da miyagun ƙwayoyi, da kuma iyakar da aka kai bayan biyu-makonni uku.

Tu tunawa game da 40% na shan kashi, Cmax jini bayyana bayan 3-7 hours. A sakamakon haka ne iya dage ga dama makonni. tafiyar matakai na rayuwa faru, yafi a cikin hanta, inda wani aiki rabi ne kafa dezetilamiodaron, wanda shine babbar metabolite. Koma tare da secreted bile da fitsari, T1 / 2 - bayan guda kashi na miyagun ƙwayoyi 3,2-20,7 h, tare da shafe tsawon far - 53 bayan ± 24 hours.

Medicine "Amiodarone": alamomi ga yin amfani da

An wajabta wani magani domin yin rigakafi da magani daga arrhythmias, wanda zai iya terminally lahani dan Adam rayukansu, kazalika da na ramin zuciya arrhythmias, na ramin zuciya flutter a m kuzarin kawo cikas kuma yi amfani da miyagun ƙwayoyi "Amiodarone."

Alamomi da damar yin amfani da miyagun ƙwayoyi da:

• atrial flutter.
• supraventricular arrhythmias.
• Wolff-Parkinson-White ciwo.
• abin da ya faru na tachycardia.
• fibrillyatsionnogo iya ventricles.
• arrhythmia tasowa saboda cardiac da jijiyoyin zuciya insufficiency.
• kullum siffofin jijiyoyin zuciya da cututtukan zuciya.
• tsokar zuciya infarction.

"Amiodarone": umarnin don amfani da

Allunan ake nufi don baka gwamnati bayan minti 15 bayan cin abinci.

A lokacin na ramin zuciya fibrillation cuta sashi shawarar da wani likita, shi ne 800-1200 MG da rana. Ya kamata a raba 3-4 receptions. A lura a cikin wannan hali yana for game 5-10 kwana don tabbatar da wani barga yanayin na haƙuri iya mika, da kuma kudi za a iya saukar da zuwa 600-800 MG da rana. Wannan m magani, wanda baya fitowa don m, wani m kashi na miyagun ƙwayoyi ciki.

Warkewa tabbatarwa lokaci ne 7-14 kwanaki, a cikin wannan lokaci na miyagun ƙwayoyi shan 200-400 MG. Irin wannan magani girma sanya dattako da haƙuri da yanayin a poslereabilitatsionny lokaci.

Sau da yawa da magani "Amiodarone" wajabta a lokacin da haƙuri shi ne a asibiti, da kuma dabara iya sarrafa likita. Wannan ya sa ya yiwu don rage girman illa da akayi daban-daban daidaita kashi na miyagun ƙwayoyi.

Lokacin da medicament cuta angina amfani da sau biyu a rana at 200 MG. Bayan makonni biyu, da sashi aka rage zuwa sau daya a rana. A kalla guda kashi kashi kada wuce 400 MG da kullum - 1200 MG.

A nada wadannan kwayoyi ga yara kamata a haifa tuna cewa kwaya shafar yaro ne da yawa fiye da ya fara tasawa. Saboda haka, da kashi da aka lasafta bisa ga nauyin da yaro. Saboda haka, daya kilogram na nauyi dole fada 10 MG na medicament. Wannan kashi dole ne a kiyaye a ko'ina cikin warkewa tsawon kwanaki goma ko har haƙuri da yanayin inganta. Nana, wannan jaddadawa don rage rabo daga 5 MG da kilogram jiki nauyi da yaro. M tabbatarwa kashi da aka dauka da kuma dogara ne a kan daya kilogram na 2.4 MG na miyagun ƙwayoyi "Amiodarone."

Alamomi da miyagun ƙwayoyi wajabta yi amfani da wani bayani dangane da aiki sashi na amiodarone hydrochloride a m cardiac arrhythmias. A wannan yanayin, da miyagun ƙwayoyi ne gudanar intravenously, sannu a hankali allura a cikin jiki tare da wani dropper. Don yin wannan, 250 ml na 5% glucose bayani for 1 ko 2 da aka sannu a hankali allura miyagun ƙwayoyi kashi na 5 MG da kilogram jiki nauyi. A wannan lokaci, da haƙuri da aka sanya idanu ta wajen ECG da jini ji karatu.

illa

Saboda haka da yawa sayen magani kwayoyi "Amidaron" a cikin kasar. Analogs ba ko da yaushe iya maye gurbin shi. Amma duk da tabbatacce sakamakon da miyagun ƙwayoyi a kan jikin mutum, da aka gano da kuma illa.

Korau cututtuka su ne yafi saboda miyagun ƙwayoyi yawan abin sama. Wannan take hakkin da zuciya da jijiyoyin jini tsarin, kamar bradycardia, sinus kumburi aiki gazawar, zuciya block, asarar daidaituwa na motsi. Har ila yau, a kan wani ɓangare na numfashi tsarin da aka gani yaxuwa interstitial na huhu fibrosis, interstitial ciwon huhu, Hamm ciwo - Rich, ciwon kirji, huhu fibrosis, tachypnea, bronchopulmonary spasms. Hanta gazawar da aka lura lokacin samun "Amidaron" shirye-shiryen. Allunan a rare lokuta sa jaundice, hepatitis, cirrhosis wani lokacin.

Gaza bada hašin kai sashi zai iya sa wani gagarumin rashin daidaituwa daga thyroid hormones, distireoza da hypothyroidism, da kuma wani sa na karin kilo. Yawan abin sama na iya haifar da rushewa daga cikin na gani na'ura, haddasa jari na lipids a cornea da almajiri. Har ila yau, akwai wata pronounced pigmentation na fata, photosensitivity, urticaria ko erythema. Ƙananan rashes aka gani fuska, alopecia, dermatitis. Side effects kuma shafa masu haihuwa aiki a cikin maza. A cikin wadannan lokuta akwai orchitis, rashin ƙarfi, kuma epididymitis. Quite rare thrombocytopenia, koda gazawar, ko angioedema vasculitis.

Contraindications ga yin amfani da

"Amiodarone" (feedback ba ko da yaushe m) da aka zaba tsananin akayi daban-daban. Akwai mutane da cewa wannan magani ba taimake ko ba su lura babu albarkacin canji a kiwon lafiya matsayi, wasu suka fara shaƙa bayan ka yi amfani da shi, ya ji zuciya palpitations. A cikin kalmomi, Propafenone shi ne iya rushe da endocrine tsarin hormones kara. Saboda haka, kafin shan wannan magani samfurin dole ba kawai hankali karanta umarnin, amma kuma kula da alamomi, illa kuma contraindications.

Saboda haka, da miyagun ƙwayoyi dole ba za a yi amfani idan akwai atrioventricular block sa 2-3, a cardiogenic buga, hyperthyroidism. Shiri "Amiodarone" ba a amfani da ta high ji na ƙwarai da aiki wakili da kuma iodo. Ban kasance tsanani take hakki na cardiac madugu da kuma aukuwa na bradycardia da syncope. Kada ka yi amfani da miyagun ƙwayoyi a lokacin daukar ciki da kuma lactation. Lactation, a lokacin da miyagun ƙwayoyi jiyya ya kamata a daina nono.

takamaiman shawarwari

Ya kamata a hankali kulawan likita warkewa magani miyagun ƙwayoyi "Amiodarone". Umarnin don amfani da shawarar yin amfani da Allunan bayan da X-ray nazari na hanta, huhu da kuma na electrocardiogram. Irin wannan monitoring kamata a da za'ayi a nan gaba, idan haƙuri ci gaba da yin amfani da magani.

A tsanani daga m events sau da yawa ya dogara da kashi, wanda yana amfani da mãsu haƙuri. Ya kamata kokarin yin amfani da miyagun ƙwayoyi a matsayin infrequently kamar yadda zai yiwu da kuma a cikin kadan yawa. Sau da yawa yana sa sababbu bugun zuciya sokewa "Amiodarone" miyagun ƙwayoyi.

Umurnai na amfani - reviews ce cewa, duk da illa, wannan magani ya ajiye fiye da daya rai - ya ce cewa pharmacological mataki da miyagun ƙwayoyi ne kiyaye domin wani makonni biyu bayan ta sakewa.

Allunan dauke da aidin, wanda na taimaka wa jari matakin na radioiodine a cikin thyroid gland shine yake. Saboda haka, a farkon warkewa magani, a lokacin da a karshen ka bukatar kullum a gwada wa adadin thyroid ji ba gani.

A lokacin warkewa baki wajibi ne don kauce wa shafe tsawon rana mai daukan hotuna, ba lallai ba ne su dauki bude rana. A miyagun ƙwayoyi ya kamata a gudanar da hankali ga tsofaffi mutane tare da general maganin sa barci ko a lokacin hanya na da oxygen magani. Tare da taka tsantsan shi ya yi amfani da direbobi motocin da rãyukansu wanda sana'a ne hade da wani musamman taro.

A lokuta da yawan abin sama iya samun worsening da illa, kazalika da hypotension, arrhythmia. Na iya faruwa bradycardia ko gazawar na AV madugu. An overabundance iya haifar da hanta tabarbarewa.

A wannan yanayin, muna bayar da shawarar nan da nan na ciki da lavage, rajista kunna gawayi, Saline laxatives shawarar mafita. Idan bradycardia injections na atropine, amfani agonists na beta-adrenergic rabe, samar pacing.

Relationship tare da sauran magunguna

Kariya kamata a yi amfani da miyagun ƙwayoyi a lokaci guda tare da sauran kwayoyi, musamman idan sun kasance daga wannan rukunin na antiarrhythmic. Ba lallai ba ne su hada shi da liyafar "erythromycin", "pentamidine" da "vincamine." Akwai wani hadarin polymorphic na ramin zuciya tachycardia a hade tare da "sultopride". An ba da shawarar hada ci CCB da beta-blockers da "Amphotericin B" da kuma kwayoyi da sa wani laxative sakamako, diuretic. Tare da kula amfani da magani a hade tare da corticosteroids, antidepressants, "Astemizole", "terfenadine." Iya muhimmanci inganta sakamakon irin kwayoyi a matsayin "Warfarin", "Phenytoin" "Tacrolimus" ko "Digoxin". Lokacin da amfani a tare da "cimetidine" slows saukar da aiwatar da metabolism a cikin jiki.

Rayuwa da kuma ajiya nagartacce

A medicament "Amiodarone", wanda mataki ne directed a kan kawar da tachycardia, na ramin zuciya fibrillation, tachyarrhythmia da atrial flutter raguwa, yana nufin shirye-shirye category "B" kungiyar. Shiryayye-rai da miyagun ƙwayoyi ne kasa da shekaru uku. Allunan ya kamata a adana a wani sanyi, duhu kuma daga isar yara.

da yin amfani da "Amiodarone" miyagun ƙwayoyi ne a tsananin sarrafawa. A girke-girke yi amfani da shi ya rubuta daga likita. A wannan yanayin, da kai dole ne a gaba daya cire.

Analogs medicament

Idan ka ba zato ba tsammani bai dace da miyagun ƙwayoyi "Amiodarone" analogs za a iya samu a wani kantin magani. Daga cikin su akwai kwayoyi kamar: "Amiodarone Belupo" da "Amiodarone Aldaron", "Angoron" da "Atlans" da kuma maye gurbin shi da magani iya "Kordaron" ko "Kordinil". Similar to "Amiodarone" a cikin effects a kan jikin mutum "Medakoron" da "Palpitin". A wasu lokuta, da miyagun ƙwayoyi aka maye gurbinsu "Sedakoronom" da "Sandoz".

Wadannan kwayoyi ko dai dauke da wannan aiki abu ko kama a su antiarrhythmic sakamako na magani "Amiodarone". Analogues sukan samar kasashen waje da kuma da dama sau mafi tsada.

shedu

Mutane da yawa marasa lafiya ce da karfafawa daga hãlãyensu bayan shan magani, "Amiodarone". Umurnai na amfani - sau da yawa miyagun ƙwayoyi analogs aka zaba bisa mutum halaye da kwayoyin - ya yi alkawarin normalize da zuciya rate, matsa lamba. Lokacin da intermittent liyafar a kananan allurai, kullum ba matsala, kuma da miyagun ƙwayoyi ayyukan yadda ya kamata.

Bayan shafe tsawon amfani da miyagun ƙwayoyi a wasu marasa lafiya bayyana shortness na numfashi, zuciya palpitations, nervousness da ciki, yanayi swings kuma Ya ƙãra thyroid hormone, a cuta daga cikin gastrointestinal fili, da kuma a wasu lokuta, tashin zuciya da kuma amai.

Mutane da yawa sosai amfani da shi a lura da angina, da kuma lura da cewa shi ne babu muni fiye da shigo da takwarorinsu. Wasu maza suna ji tsoro, ka dauki da miyagun ƙwayoyi, domin shi ne a cikin su, yana da ikon sa wani adadin na cutar kansa. An yi imani da cewa da miyagun ƙwayoyi ya kamata a dauka kawai a karkashin yanayin da ke barazana rayuwar mutum, a duk sauran yanayi, ya kamata dubi zuwa ga wani madadin. Bugu da kari, da kwamfutar hannu zai iya samun mummunan tasiri a kan namiji haihuwa aiki, wanda shi ne ma a yi la'akari a su liyafar.

Amma duk da haka saboda mutane da yawa miyagun ƙwayoyi "Amiodarone" shi ne wata dama,, godiya ga wanda cutar ta janye, amma mutumin ya zauna da rai. Ba da cewa analogues zai zama kamar yadda tasiri. Saboda haka, a lura da cututtukan zuciya, kada hana tasiri da miyagun ƙwayoyi kashe, musamman idan likita ya bada shawarar da shi.