Avidity - me ake nufi? Avidity IgG antibodies zuwa Cytomegalovirus: siffofin da kuma decrypting

Yanzu fiye da taba, yana da muhimmanci a farkon ganewa da kuma rigakafin cututtuka. Wannan na bukatar high quality, kuma m bincike dabaru. A bisa ga al'ada asibitin yana amfani da serological hanyoyin kayyade tsanani daga cikin tsari da kuma gaskiyar hijira kwayar, kwayan da fungal cututtuka. Amma wadannan gwaje-gwaje ba m isa ya rarrabe tsakanin primary kamuwa da cuta, reinfection cutar ta koma dawowa. Saboda haka, da zamani masana kimiyya samarwa a hanya domin kayyade avidity na IgG-antibodies.

Avidity: abin da ake nufi?

Rarrabe Concepts na dangantaka da avidity. Dangantaka - a thermodynamic halayyar quantitatively kwatanta da ƙarfin da hulda da antibody da antigen na daya. Bi da bi, da avidity kayyade bond ƙarfi tsakanin antigen da antibody. Wadannan Concepts an kai tsaye alaka da juna. A mafi antigen, niƙaƙƙun gaɓãɓuwa akai, da karfi da connection. Rarrabe low kuma high avidity.

Wanda ke nufin high avidity? Bari mu bincika. Lokacin da antigens shiga jiki a karo na farko, suka ta da B Kwayoyin cewa samar da immunoglobulins. Farko shi IgM, amma sai aka maye gurbinsu da IgG. Bayan na farko lamba na dangantaka, ya kuma inganta avidity, low, kamar yadda kawai jiki ta kare hanyoyin daidaita zuwa wani sabon pathogen. Bayan makonni bakwai da, IgG «balagagge», suna sosai musamman, sabili da haka, babban avidity. Kuma a yanzu, a game da sake kamuwa da cuta, da na rigakafi da tsarin za su kasance a shirye don amsa da sauri zuwa barazana.

avidity index

Level avidity inversely dogara a kan antigen kashi da yanayi da matakin maye gurbi a cikin adam Kwayoyin. Karamin da farko kashi, da hakan da dangantaka, da kuma mataimakin versa.

Sa'an nan pathophysiology da immunology fuskanci sabon abu na dakushe rigakafi da shekaru. Mu yi tunani da kuma deduced wasu rabo, kira avidity index. Me ake nufi da avidity index? Wannan adadi ya nuna zumunta aiki na immunoglobulin su ɗaure antigen. A index a cikin kewayon tsakanin 15 da kuma kashi 50 cikin nuna primary kamuwa da cuta, idan darajar wuce kashi 50, sa'an nan da mãsu haƙuri ya riga ya sha wahala daga cutar.

rubella

A rubella virus yana da wani musamman mummunan tasiri a kan tayin, don haka yana da muhimmanci domin sanin ko expectant uwa ba shi da lafiya tare da cutar, ko kafin daukar ciki ta kamata a alurar riga kafi. Domin bincike amfani serological gwaje-gwaje domin dangantaka antibodies da antigens. Idan immunoglobulins kusan gaba ɗaya saboda kwayar gaɓũɓuwa, don haka high avidity antibodies. Wannan na iya nuna ko dai a baya kamuwa da cuta, da kuma mai kyau rigakafi bayan alurar riga kafi.

Wani lokaci, saboda da ruri daga lymphocyte kwafi masu kunnen doki da rubella cutar da aka gano ƙarya m dauki ga immunoglobulin M. Bugu da kari, irin wannan a sakamakon za a iya gani a cikin wadanda marasa lafiya a wadda dagagge jini rheumatoid factor. Kawai akwai wata gaban antibodies da cewa suna da low avidity. Abin da ake nufi? Wannan za a iya gani a matsayin hujja da wani primary kamuwa da cuta da rubella cutar. A cutukan shi ne kai tsaye nuni ga zubar da ciki.

toxoplasmosis

Matsayin mai mulkin, wannan kamuwa da cuta da yake boye, kuma bayyanuwar asibiti cututtuka da samu Pathology (misali, kamar ƙãruwa Lymph nodes) yana mai low bincike darajar, a lokacin da kuke bukata don gano yadda dogon wani mutum ba shi da lafiya. Tabbatar da dalilin da IgG avidity antibodies ne sosai musamman da kuma m hanya domin ganewar asali m primary toxoplasmosis, wanda shi ne da muhimmanci musamman a lokacin da nazarin mata masu juna biyu da ya kawar da yuwuwar hadarin nakasar toxoplasmosis a yara.

Har kwanan nan, da kawai samuwa serologic kima domin sanin mai tsanani daga cikin tsari da aka gano immunoglobulin aji M da kuma kara a titer na IgG. Idan a cikin mako guda da adadin immunoglobulin G karu sau hudu ko fiye, shi ne kai tsaye ba da shaidar cuta ci gaban.

Ko da tare da serological gwaje-gwaje likita ne da wuya domin sanin daidai lokacin da wani mutum ya kamu, kamar yadda immunoglobulin M da kuma G iya dage na dogon lokaci a cikin jini. Saboda haka, kawai abin dogara hanya ne domin sanin avidity. Abin da ake nufi? Ƙananan dangantaka da haka avidity Toxoplasma baya shiga cikin jiki. Haka kuma, kwanan nan ya bude Hanyar raba low dangantaka da m dangantaka antibodies ga sauƙi na kirgawa da kuma kayyade irin kamuwa da cuta.

Herpes simplex cutar

Mafi yawan mutane a duniya da ke kamuwa da herpes simplex cutar. Wani ta cuta yakan faru a cikin wani latent form, kuma amma mafi yawan cututtuka ne kiyaye, ko da sun kasance qananan. Bugu da kari, akwai wasu matsaloli da yadda za a ƙayyade da avidity na herpes. Abin da ake nufi a yi? Wannan cutar ne halin da atypical antibody, yana iya zama a cikin jiki domin rayuwa, bada ƙarya-tabbatacce, kuma ƙarya-korau sakamakon. Arya rashinta aka ƙaddara lokacin da immunoglobulins ba kafa ko a cikin magani a alamarsu yawa. Arya-tabbatacce sakamakon faruwa saboda tsawo zagawa da antibodies ko da wani kamuwa da cuta.

Bugu da kari, shi yana da giciye-amsawa antigens cewa mimic yadda histocompatibility antigens na al'ada jikin kyallen takarda, da kuma wasu siffofin herpes cutar. Wani ƙarya tabbatacce halayen ana ƙaddara da sakandare kamuwa da cuta da mutum immunodeficiency cutar.

cytomegalovirus kamuwa da cuta

Wannan cutar ne ya fi kowa m ga zubar da ciki a farkon daukar ciki. A hadarin kamuwa da cuta dogara a kan matakin antibodies a cikin mahaifiyarsa a lokacin da ganewa. Idan da farko kamuwa faru a farko trimester, damar kamuwa da cuta shi ne 50 bisa dari.

Me ake nufi da avidity for CMV? Kamar yadda a duk wasu lokuta, da tabbatar da dalilin da dangantaka da IgG da IgM m dauki a daidai tabbatar da ko ƙaryatãwa game da kasancewar wani primary CMV kamuwa da cuta. Bugu da kari, shi ba ka damar kauce wa m da tsada hanyoyin expectant uwa.

Hepatitis C cutar

Ganewar asali na hepatitis dangane da kayyade takamaiman alamomi na nuna ci gaban da kamuwa da cuta tsari. A wannan yanayin, IgM iya faruwa da yawa daga baya, fiye da na IgG, ko lokaci guda tare da su. Yana da wuya a tantance farko na cutar da kuma lokacin farko kamuwa da cuta.

The kawai m serological bincike ne serokoversiya da IgG avidity on. Abin da ake nufi? Idan avidity index ne low, wannan shi ne kai tsaye tabbaci na farko kamuwa da cuta. A cikin hali na kayyade a high avidity IgG aji antibodies iya amincewa ce kullum hepatitis ko hijira.