"Amphotericin B": wa'azi, ginshikai na mataki. Shedu game da miyagun ƙwayoyi

Fungal fata kawo babba rashin jin daɗi ga mãsu haƙuri. Haka kuma, irin wannan cututtuka. Saboda haka, a lokacin da farko alamun da naman gwari dole ne dole koma zuwa wani gwani. Bayan wucewa da likita gwaje-gwaje da kuma sauran Nazarin likita zamar masa dole ya nada wani haƙuri inganci da kwayoyi.

Sau da yawa sosai, domin lura da fungal cututtuka ta amfani da dama man shafawa da kuma kwayoyi. Duk da haka, mafi likitoci sun ce irin wannan pathological yanayin ne mafi kyau bi da da igiyar jini allura. Bayan injections da miyagun ƙwayoyi nan da nan za a fara aiki a kan kwayoyin da cewa nuna wani musamman ji na ƙwarai to shi.

A mafi inganci da tasirin hanyoyin da za a kawo magani domin kawar da fungal cututtuka "Amphotericin B". Umurnai, siffofin saki da kuma shedu game da miyagun ƙwayoyi aka gabatar a kasa.

Form, abun da ke ciki, description da kuma marufi da kwayoyin

Saya dauke da miyagun ƙwayoyi iya zama a cikin wadannan siffofin:

• Lyophilisate "Amphotericin B". Reviews sun ruwaito cewa wannan nau'i na da miyagun ƙwayoyi ne a porous hygroscopic taro na rawaya launi ba tare da wani pronounced wari. An tsara domin shiri na jiko bayani. The aiki bangaren na miyagun ƙwayoyi ne amphotericin B. A aka gyara an yi amfani da matsayin karin abubuwa irin monobasic sodium phosphate da deoxycholic acid. A sayar da medicament aka kawota a vials na 10 ml, da kuma takarda cartons.

• Maganin shafawa "Amphotericin B". Aikace-aikace na nufin wannan ne da aka nuna a matsayin karin magani a hade far. Antifungal shafawa amfani kawai azahiri. Shi ne rawaya kuma yana dauke da aiki sashi daga cikin wannan sunan. Amma ga ƙarin aka gyara abin da ake amfani da ma'adinai da man fetur, petrolatum, kuma polysorbate 80. Buy wannan magani zai iya zama a cikin akwatin na 30 ko '15

Ginshikai na mataki na miyagun ƙwayoyi protivogribkvogo

Mene ne magani "Amphotericin B"? Umurnai na amfani (Allunan da wannan aiki sashi samu quite matsala) rahoton cewa yana da wani macrocyclic polyene kwayoyin da antifungal aiki. An samar da Streptomyces nodosus, da kuma bayar da fungistatic da fungicidal mataki (dangane da taro na miyagun ƙwayoyi a nazarin halittu ruwaye da laulayi).

Bayan da miyagun ƙwayoyi shigar da jini rafi da shi ta ɗaure zuwa sterols cewa an samu a cikin cell membranes na fungi kula da miyagun ƙwayoyi. A sakamakon irin wannan daukan hotuna da aka gaji da damuwa da permeability da kuma cire kwayuka aka gyara faruwa a cikin extracellular sarari.

A miyagun ƙwayoyi ne "amphotericin B" shi ne aiki da yawa damuwa da moderately aiki da protozoa fungi.

Ya kamata kuma a lura da cewa ta hanyar wannan yana nufin resistant Fusarium spp. kuma Pseudallescheria boydii. Bugu da kari, wannan magani ba tasiri da rickettsiae, kwayoyin da ƙwayoyin cuta.

A sanadin motsi kaddarorin da miyagun ƙwayoyi

Yanzu ka san cewa shi ne irin wani antifungal wakili, kamar yadda "Amphotericin B". Ginshikai na mataki na wannan wakili da aka bayyana a sama.

Bayan igiyar jini gwamnati da miyagun ƙwayoyi a guda kashi a cikin jini nan da nan halitta ta maida hankali tasiri wanda yana kiyaye ko'ina cikin yini. C sunadaran ta ɗaure ga kayan aiki da jini da kashi 90 cikin dari.

An sano medicament rarraba a cikin hanta, huhu, koda, saifa, tsoka, adrenal gland shine yake da kuma sauran gabobin da kyallen takarda. Its taro a pleural effusion, peritoneal da synovial ruwaye, kazalika da ruwa-ruwa mutumci kai 2/3 na maida hankali a cikin jini.

Wannan hanya yana nufin ba a sani ba. A fitsari, bile, kuma game da 98 bisa dari na miyagun ƙwayoyi ne ba a cikin nau'i na metabolites. Nuna sannu a hankali ta hanyar da kodan. A farko rabin-rai da miyagun ƙwayoyi a manya ne 24 hours, a cikin yara - 6-40 hours, da kuma jariri - 20-60 hours. Terminal rabin rayuwa ne kwanaki 15.

alamomi da kwayoyin

Wanne ya bi cututtuka magani "Amphotericin B"? Ya aka nada a m, rai-barazanar fungal cututtuka da aka sa ta mai saukin kamuwa microorganisms:

• histoplasmosis, watsa cryptococcosis, coccidioidomycosis.
• cryptococcal meningitis, paracoccidioidomycosis, chromomycosis.
• meningitis sa da sauran fungi, North American blastomycosis.
• metastatic da kuma cin zali aspergillosis, phycomycosis (zygomycosis).
• samar da watsa candidiasis gialogifomikoza.
• Tsari mai sarrafa kansa mycosis, na kullum mycetoma.
• watsa sporotrichosis, na ciki cututtuka (ciki har da peritonitis).
• endophthalmitis, endocarditis, fungal sepsis.
• Visceral leishmaniasis, fungal urinary fili cututtuka.
• American cutaneous visceral leishmaniasis.

Contraindications antifungal wakili

Ka yi la'akari da abin da jihar su yi amfani da haramta miyagun ƙwayoyi "Amphotericin B" (Allunan daga wani naman gwari na wannan sunan ba ƙãga). Bisa ga umarnin, wannan kayan aiki ne contraindicated:

• kullum na koda gazawar.
• a hypersensitivity.
• a lokacin shayarwa.

Tare da kula aiki medicament amfani a koda cuta (ciki har da glomerulonephritis), amyloidosis, hanta cirrhosis, hepatitis, anemia, agranulocytosis, daukar ciki da ciwon sukari.

Lyophilisate "Amphotericin B": umarnin don amfani da

Ga shiri na wani igiyar jini magani bayani da aka yi amfani da tare da wani na farko taro na 5 MG / ml. Ta hanyar wani sirinji 10 ml na bakararre ruwa ga allura don yin vial da medicament. Next, da abinda ke ciki girgiza ta samar da wata m colloidal ruwa.

Igiyar jini miyagun ƙwayoyi ne an gudanar a cikin sa'a guda a karkashin iko da jini, yanayin jiki da kuma zuciya rate na haƙuri. A da kyau haƙuri miyagun ƙwayoyi da aka bada shawarar kullum sashi na 0.25-0.3 MG da kg jiki nauyi (dangane da tsananin cutar).

A cututtuka na zuciya da jini, ta ƙara ji na ƙwarai da kasa koda aiki, magani an qaddamar da kananan dosages (5-10 MG), wanda aka hankali ya karu da 5-10 MG da rana da kuma aka gyara zuwa 0.5-0.7 MG da kg.

Lokacin da sporotrichosis Hakika kashi magani ne 2.5 g, da kuma tsawon lokaci na far - domin akalla 9 months.

Lokacin da kayan aiki aspergillosis sashi ne 3.6 g, da kuma tsawon lokaci na magani - akalla watanni 11.

Babies a farkon far gudanar 0.25 MG da kg jiki nauyi da rana, sa'an nan ya karu sannu a hankali zuwa a kalla kashi (1 MG da kg).

Maganin shafawa "Amphotericin B": umarnin don amfani da

Allunan a karkashin wannan ciniki sunan a Pharmacy ba a sayar. Saboda haka, domin maye wannan magani ya kamata shawarci likita.

Idan dole yin amfani da maganin shafawa "Amphotericin B" bakin ciki Layer ne amfani da abin ya shafa yankunan kullum sau biyu. A lura Hakika dogara da samuwa shaida:

• tare da candidiasis na fata folds - game da 1-3 makonni.
• tare da kyallen rash in yara - kamar 7-14 kwana.
• tare da paronychia da interdigital sarari galaba - 2-4 makonni.

illa

Shiri "Amphotericin B" na iya haifar da wadannan illa:

• ciwon kai, seizures, na gefe neuropathy, mai shudewa vertigo, encephalopathy.
• asarar ci, amai, dyspepsia, tashin zuciya, gastralgia, zawo, hepatotoxicity, m hanta gazawar, jaundice, hepatitis, melena, haemorrhagic gastroenteritis.
• normochromic normocytic anemia, leukopenia, clotting cuta, thrombocytopenia, agranulocytosis, hemolytic anemia, eosinophilia, leukocytosis.
• Heart hangen nesa, ji hasara, diplopia, tinnitus.
• tachypnea, dyspnea, na huhu edema, arrhythmia da hypersensitivity pneumonitis.
• rage ko kara jini, itching, canje-canje a ECG sigogi, zuciya rashin cin nasara, bugu, zuciya rashin cin nasara.
• anaphylactoid halayen, sneezing, nephrogenic ciwon sukari insipidus, bronchospasm, nephrocalcinosis, rash, eksfoliativiy dermatitis, mai guba epidermal necrolysis
• koda gazawar, hypokalemia, gipostenuriyu, koda tubular acidosis, Stevens - Johnson ciwo, m na koda gazawar, oliguria, anuria.
• thrombophlebitis kuma ƙone a allura site.
• zazzabi, myalgia, nauyi asara, arthralgia, janar rauni.

lokuta da yawan abin sama

Lokacin gudanar da manyan allurai da magani mai haƙuri iya daina numfashi da kuma zuciya. Saboda haka, a cikin shakka daga far kamata tsananin bi da shawarar sashi likita. Shi ne kuma dole ka saka idanu da na numfashi da kuma cardiac, koda da hanta aiki, na gefe jini hoto, kazalika da abun ciki na Wutan.

Karfinsu tare da sauran magunguna

A medicament "Amphotericin B" iya fadada ko attenuate sakamakon wasu kwayoyi, kazalika don su kara yawan guba. Saboda haka, wannan magani an wajabta, tare da taka tsantsan a cikin magani.

A cikin ganawa da ya ce wakili zuwa haƙuri, tabbata a sanar da likita game da shan wasu kwayoyi. In ba haka ba, da yin amfani da "Amphotericin B" (igiyar jini) na iya zama detrimental ga kiwon lafiya da kuma sauran alheri mutum.

takamaiman shawarwari

• A miyagun ƙwayoyi ne "amphotericin B" za a yi amfani ne kawai domin lura da rai barazana da kuma m fungal cututtuka.
• Tare da shafe tsawon amfani da alama na mai guba effects ƙaruwa.
• Lokacin da amfani da miyagun ƙwayoyi ya zama katse anemia.

reviews

Yanzu ka san yadda da miyagun ƙwayoyi abubuwa "Amphotericin B". A dakatar da wannan sunan shi ne ba a sayar a Pharmacy. Saboda haka, domin baka da gwamnati, ya kamata ka zabi wani magani da irin wannan mataki.

Ga cewar mafiya yawan marasa lafiya, dauke da wani wajen yadda ya kamata a magance da aiki. An daidai yi wa fungal fata raunuka, kawar da jiki da kuma m? Unci daga mãsu haƙuri.

Babban drawback wannan miyagun ƙwayoyi ne a manyan yawan illa. A lokacin jiyya, wannan kayan aiki da m halayen na iya faruwa a kan wani ɓangare na duk gabobin da kuma tsarin. Saboda haka, ya kamata a yi amfani ne kawai a musamman alamomi.