"Ursofalk": analogues, umarnin don amfani da saki fom

Medicament "Ursofalk" umurci manual gano a matsayin magani da m bakan da aiki, wanda yana da, da sauransu, hepatoprotective, cholelitolitic, immunomodulatory Properties. Har ila yau, da miyagun ƙwayoyi muhimmanci rage jini cholesterol matakai.

aiki kayan

The aiki sashi daga cikin medicament abubuwa ursodeoxycholic acid. Shi ne yanzu a wasu adadin a mutum bile, amma a sakamakon wasu cuta aiki hanta kira da kuma daidai da, da abun ciki na dũkiyõyinsu a bile za a iya rage.

Ursodeoxycholic acid a matsayin babban sashi ne yanzu ba kawai a cikin shirye-shiryen "Ursofalk". Analogs na abun da ke ciki da kuma pharmacological Properties - wadannan kwayoyi a matsayin "Ursosan", "Ursol", "Urdoksa". Magana game da su a kasa.

Warkewa effects "Ursofalk" wajen

• Choleretic sakamako ne da rage a cikin adadin hydrophobic bile acid da kuma kara da saki a cikin hanji lumen. Bugu da kari, da miyagun ƙwayoyi saboda kasancewa a cikin sadarwar da ileum rage-rage rabe hydrophobic sha mai guba acid.
• Immunomodulating mataki ne ya sa ta gaskiya cewa ursodeoxycholic acid ne iya rage magana a hepatocytes Hla kwayoyin na farko aji, da kuma cholangiocytes - Hla kwayoyin na biyu aji. Har ila yau magani rage kira na pro-kumburi cytokines.
• A cytoprotective sakamako ne da ikon na aiki abubuwa su shiga cikin lipid Layer na jikin tantanin, sakamakon jikin tantanin stabilizes ta m Properties suna inganta.
• Hypercholesterolemic sakamako dogara ne a kan raguwa a cikin ileum sha da kuma rage cholesterol kira a cikin hanta, kazalika da ta tukar tumbi a bile.

Bayan sama effects, da miyagun ƙwayoyi "Ursofalk" (umarnin don amfani evidenced) suranta wani ruwa crystal tare da cholesterol kwayoyin da ta rage lithogenicity bile. Saboda hira da cholesterol mahadi rage samuwar duwatsu ne su rushe.

Pharmacokinetics

Wadannan baka gwamnati da miyagun ƙwayoyi a cikin kananan hanji da ake tunawa ursodeoxycholic acid, da sha aka mamaye aiki kai a cikin ileum a cikin m rabo, kuma ta m kai - a cikin jejunum da ileum a cikin sama ɓangare. Aƙalla 60-80 bisa dari na kashi samun shiga cikin jini.

The aiki abu ne metabolised a cikin hanta da kuma jera disintegrates a cikin hanji, wadda take kaiwa ga samuwar guba bakwai-keto lithocholic acid, wanda, bi da bi, da ake tunawa a cikin jini, kuma don a kananan har a cikin hanta detoxifies. Half-rai da kwayoyi - uku - biyar kwana. An yafi excreted a cikin faeces kamar yadda metabolites.

Alamomi ga yin amfani da

Shiri "Ursofalk" umurci manual nuni amfani da cututtuka na gall mafitsara, da hanta, tare da wani karuwa a jini cholesterol, cholestasis, hanta wasu rage ayyuka. Daga cikin irin wannan ailments za a iya ambata biliary cirrhosis (primary), biliary reflux gastritis, sclerosing cholangitis (primary), biliary reflux esophagitis, hepatitis na daban-daban etiology, cystic fibrosis.

Da miyagun ƙwayoyi an wajabta, a gaban gallstones, amma kawai idan suka rentgennegativnye a diamita, su size bai wuce goma sha biyar millimeters, kuma da mãsu haƙuri ba rushe aiki na gallbladder. A medicament ana amfani a yanayin saukan hanta yawan guba (msl, barasa mai guba), ta Pathology tare da cholestasis (a cikin yara), biliary dyskinesia, atresia na intrahepatic bile ducts. Ya Take marasa lafiya a kan parenteral abinci mai gina jiki, domin kawar da stagnation na bile, kazalika da mutanen da suka yi tiyata ga wani hanta dashi.

A matsayin prophylactic wakili gudanar miyagun ƙwayoyi "Ursofalk" (kwayoyi analogs kuma za a iya amfani da wadannan lokuta) lokaci guda tare da liyafar da kwayoyi wanda zai adversely shafi aiki na hanta (hormonal hana, kwayoyi da cholestatic sakamako).

Saki tsari da kuma abun da ke ciki

Biyu siffofin saki da miyagun ƙwayoyi yana da "Ursofalk": dakatar (babu analogues, samar a Switzerland) da kuma capsules (analogs ake samar a Jamus). A farko version na miyagun ƙwayoyi da ake amfani da yafi ga yara ko mutane da wahala hadiya. Gelatin capsules ne opaque, tukuru, murfin da jiki suna fentin fari, ciki - fari granules ko foda. Samuwa a fakitoci na 10, 25, 50 ko 100 guda. The dakatar ila yau yana da farin launi, halin da kama daidaito, ya ƙunshi iska kumfa, shi yana da lemun tsami turare. Samuwa a cikin kwalabe na 250 milliliters, cikakken kewaye aunawa cokali.

250 MG na ursodeoxycholic acid da aka dauke a cikin kwantena shiri, wannan adadin na aiki abu ba a biyar milliliters (daya diba) slurry "Ursofalk". A syrup qunshi karin aka gyara: glycerol, anhydrous citric acid, xylitol, propylene glycol, sodium chloride, microcrystalline cellulose, benzoic acid, lemun tsami dandano, sodium citrate, tsarkake ruwa, sodium cyclamate. Secondary sinadaran a capsules gabatar colloidal silicon dioxide, titanium dioxide, sodium lauryl sulfate, masara sitaci, magnesium stearate, gelatin, tsarkake ruwa.

Yadda za a yi "Ursofalk"

A medicament a yanayin saukan guda liyafar manufa nufin ya sami da yamma. Kwantena da aka yi lõma, ba tare da daukan taban, da kuma wanke saukar da ruwa a hannun dama yawa. Kamar yadda muka rigaya muka gani, "Ursofalk" magani ga yara shi ne mafi alhẽri a yi amfani a cikin wani nau'i na dakatar (syrup). A sashi ya kamata a lasafta likita, dangane da yanayin da cutar da kuma halaye na haƙuri ta jiki. Jarirai (tare da wani nauyi na biyar kilo) ya kamata a ba a lokacin kwanta barci kwata ma'auni cokali slurry.

Yawanci ga hanta kullum kashi na manya ne 10-15 MG da kilogram jiki nauyi, cikin shakka daga far yana daga watanni shida zuwa shekaru biyu, da aka ba da shawarar a wannan yanayin karya a liyafar medicament. Don mutane da biliary reflux oesophagitis ko biliary reflux gastritis kullum kashi "Ursofalk" miyagun ƙwayoyi - 250 MG magani - goma - kwana goma sha huɗu. Lokacin da sclerosing cholangitis kuma biliary cirrhosis da rana, yawanci rubũta samun 10-15 MG da kilogram jiki nauyi, amma idan ya cancanta, da kashi ya karu zuwa 20 MG da 1 kg. Far yawanci yana daga watanni shida zuwa shekaru biyu. Marasa lafiya da cystic fibrosis dauki magani kullum a kashi na 20-30 MG da kilogram na jiki nauyi a kan watanni shida zuwa shekaru biyu. A cikin hali na hanta yawan guba da aka nuna don gudanar da miyagun ƙwayoyi a kullum kashi na 10-15 MG da kilogram na jiki nauyi ga shida - watanni goma sha biyu.

"Ursofalk" magani. analogs

A kamanta halayyar magani da kwayoyi kama a abun da ke ciki da kuma pharmacological Properties.

• Drug "Ursosan". Wannan samfurin ne kerarre a Jamhuriyar Czech da kuma Jamus, shi ne samuwa ne kawai a cikin nau'i na capsules. Ginshikai na mataki a cikin irin wannan magunguna. Duk da haka, therapists, hepatologists, cutar da likitoci a kan wannan tambaya da miyagun ƙwayoyi ne mafi alhẽri, "Ursosan" ko "Ursofalk" gaba ɗaya amsa da cewa shi ne fin so zuwa zabi na biyu. Irin karshe da aka yi da masana kan nasu na asibiti lura da feedback daga marasa lafiya. Medicine "Ursofalk" da aka canjawa wuri sauki fiye dauke analog, shi kuma za ta koma daidai da aikin jiha na hanta. Amma kar ka manta game da sirri halaye da kwayoyin, akwai mutanen da suke nufin "Ursosan" taimaka mafi alhẽri. Bugu da kari, da miyagun ƙwayoyi ne daraja kadan mai rahusa: fakitin da 50 capsules za kudin 650-830 rubles, yayin for 50 capsules da magani "Ursofalk" zai biya 850-1200 rubles.
• "Urdoksa" wajen. A Generic magani da aka samar domestically. Duk da haka, samar da wani pharmaceutical kamfani sayan dole sinadaran da kasashen waje, da kuma a Rasha a can ne kawai da miyagun ƙwayoyi masana'antu tsari. Yana kuma shi ne samuwa a capsules, da farashin for 50 guda dabam tsakanin 440-960 rubles. Dukansu kwayoyi ne pharmacologically kama, a cikin samar da gagarumin bambanci sakamako ba ya lura.
• "Ursol" magani. Medicine, kamar yadda a baya harka, aka sanya a Rasha. Duk da haka, mutane da yawa sun ce duk wadannan kudi ne shi ne mafi alhẽri dissolves duwatsu a cikin gall mafitsara. Amma akwai wadanda suke da tasiri na magani ya mafi girma a lokacin da shan miyagun ƙwayoyi "Ursofalk". A capsules da irin wannan tsarin, don haka ba, baicin daya ko sauran zaɓi ne da wuya. Idan ka mayar da hankali a kan farashin, shi ne mafi alhẽri saya da miyagun ƙwayoyi "Ursol" shi ne mai rahusa - 460-905 rubles for 50 capsules.

illa

medicament "Ursofalk" Pretty da kyau jure da marasa lafiya. Analogs miyagun ƙwayoyi ma halin da kyau tolerability. A wasu lokuta, a lokacin jiyya akwai calcification na gallstones ci gaba mushy stools, zafi a cikin epigastric. Bugu da ƙari, za ka iya ci gaba da wani alerji a cikin nau'i na pruritus, urticaria. Rahotanni na yawan abin sama da aka ruwaito to date.

contraindications

High sirri ji na ƙwarai to da miyagun ƙwayoyi aka gyara ne dalilin hakan da amfani. Magani ne contraindicated ga mutanen da tare cholangitis, ko occlusion na cystic bile bututu, m cholecystitis. Kada rubũta da miyagun ƙwayoyi zuwa marasa lafiya fama da wani take hakkin da mota aiki na gallbladder, bile colic.

Pregnancy kuma lactation

A cewar nazarin, ursodeoxycholic acid bai nuna mutagenic, teratogenic, embryotoxic aiki, amma da ikon shiga gematoplatsentarny shãmaki, kuma shafi cikin shakka daga ciki ba a karatu har zuwa karshen. Saboda haka, kai da magani "Ursofalk" a lokacin haihuwa kawai a lokacin da ya cancanta, kuma wajabta ta likita. Experience a cikin yin amfani da magani a cikin lactation lokaci ne ba samuwa.

Hulɗarka tare da sauran kwayoyi

Lokaci daya da magani tare da antacid shiri hada da aluminum hydroxide, kuma da magani "Colestipol" da "Cholestyramine" kaiwa zuwa runtse tsari sha na aiki abu. Da miyagun ƙwayoyi iya canza taro a jini jini miyagun ƙwayoyi "Tacrolimus". Idan akwai bukatar ga hadin gwiwa da yin amfani da irin wannan magunguna ya kamata a dauka a kan jinkiri na akalla sa'o'i biyu.