Latest ƙarni na statin kwayoyi: abũbuwan amfãni, farashin, reviews

Class statin kwayoyi da aka hada a matsayin hanyar zuwa rage adadin magani cholesterol, da rage zuciya da jijiyoyin jini hadarin. Na dogon lokaci masu bincike da kuma likitoci aiki kawai da kwayoyi, "Lovastatin," "Pravastatin" "Simvastatin", "Fluvastatin." An sa'an nan hada "Atorvastatin" da "Rosuvastatin" - shi ne latest ƙarni na statins, ko kuma wajen, mafi inganci da kwayoyi a cikin wannan category. Shi ne kuma a halin yanzu underway wajen samar da sabon, cewa shi ne ma fi aminci da tasiri statins, daga abin da ya fi rare nasa ne da "pitavastatin."

Janar pharmacological halaye na statins

All statins fada cikin category na kwayoyi da shafi sia metabolism a cikin jikin mutum. A ilimin Halittar Jiki Therapeutic Chemical Nau'in System magunguna suna sanya code S10AA da lãbãri a gare hanawa na HMG-CoA reductase. Inhibiting Activity wannan enzyme, suka rushe kira na cholesterol, magani wajen rage yawan ta adadin. statins Wannan mataki damar cimma shawarar yawa na low-yawa lipids a cikin jini.

Wadannan effects sa shi yiwuwa a rage cikin kudi na ci gaba atherosclerotic plaque. Har ila yau kwayoyi hana ta abin da ya faru. Ko da shi ke samuwa a cikin m sakamako na statins: su dattako da endothelium na atherosclerotic plaque, a wannan batun, rage da alama na jijiyoyin zuciya thrombosis, mukaddashin da wani daban-daban inji fiye da antiplatelet far. Haka kuma, a hade da yin amfani da wadannan kudi damar fi don rage alama na ciwon zuciya. Saboda statins aka shigar a kan farashin da shi ne cikakken wajaba a kansa.

Musamman statins rarrabuwa

Akwai da dama hanyoyin da rabo a cikin azuzuwan da kwayoyi. Su za a iya gani cikin sharuddan fasali kira. Har ila yau, tun da magani daga daban-daban statins bukatar kasafi a daban-daban allurai ne m don gabatar da wani rarrabuwa dangane da shawarar dosages. Nau'in ƙarnõni kama da wannan:

• Na tsara "Simvastatin", "Pravastatin", "Lovastatin".
• II tsara, "Fluvastatin."
• III tsara "cerivastatin," "Atorvastatin".
• Generation IV "pitavastatin," "Rosuvastatin."

All statins kasu kashi wucin gadi hada daga albarkatun kasa, da na halitta. A karshen hada da "Lovastatin," "Pravastatin" da "Simvastatin". Roba kwayoyi ne sauran: "Fluvastatin," "Atorvastatin", "Rosuvastatin" da "pitavastatin."

Nau'in statins a allurai dangane da aikace-aikace

All azuzuwan da kwayoyi, ciki har da latest ƙarni na statins, intelligently kasu kashi low kashi (8 MG), srednedoznye (10-40 MG) na high (40-80 MG). A musamman:

• high-mai kumburi kwayoyi ( "atorvastatin", "Lovastatin" "Fluvastatin");
• srednedoznye kwayoyi ( "simvastatin", "pravastatin", "Rosuvastatin");
• low kashi kwayoyi ( "pitavastatin").

Wannan rarrabuwa nuna yiwuwar danganci kuma su warkewa kewayo. A musamman, high-kwayoyi da wani sakamako a high yawa, yayin da kyau jure. Srednedoznye kwayoyi, amma "rosuvastatin" kasa da jure a high allurai, amma da mai kyau sakamako.

Srednedozny statin "Rosuvastatin" za a iya gudanar a wani babban sashi (80 MG), idan ya cancanta, ko saboda wani isasshe cikakken akan rage total cholesterol kuma low-yawa sulusi da murabba'i cewa sau da yawa ba a bukatar. "Pitavastatin", kuma ya aikata bukatar da manufa a cikin m yawa, saboda abin da kasada na m halayen da yawa sau da ƙananan fiye da abin da na aji takwarorinsu.

A tarihin na ci gaba da kuma gabatarwar statins

History of statins ne rigima sosai. Da farko, su ci gaba ne ƙwarai hampered da rashin sanin cholesterol metabolism kuma da alama na tasowa atherosclerosis, dangane da matakan da jini lipids. Bugu da ƙari, da zarar hada gopoholesterinemicheskie nufin hana microflora a al'adu kyawon yi nufin samu tsarki penicillin. Opening na cholesterol-ragewan mataki na wani yawan abubuwa samar da fungi, kuma ya sa nazarin statins.

Ya zama na farko da statin, compactin, kuma ba gabatar a cikin asibiti yi saboda da yawa na saɓani ra'ayin game da makamantanta. Yana da aka ware daga na al'ada Penicillium cetrinium. Sa'an nan, daga wani al'adun Monascus ruber ya zama ruwan dare monacolin K, ya jadadda mallaka a watan Fabrairu 1979. A Yuni 79th jadadda mallaka da kuma mevinolin, wanda daga baya ya fara kawo sunan "Lovastatin". Wannan magani da ake amfani a asibitin, bayan shi da aka ware ko hada da latest ƙarni na statins.

A yawa na adawa da ra'ayoyi statins hana ci gaban, bayan da aka yanke shawarar gudanar da manyan sikelin-gwajinsu. Don kwanan wata, mafi girma mafi amfani shi ne nazari na Scandinavian Simvastatin Survival Nazarin. Taqaitaccen da sunan da ake «4S». An cikakken karyata yiwuwar carcinogenic cututtuka da suka shafi miyagun kwayoyi gwamnati, da kuma tabbatar da cewa su yi amfani da muhimmanci ƙara rayuwa da kuma rage abin da ya faru na m jijiyoyin zuciya pathologies.

Abstracts domin amfanin statins

Lokacin da farko taro na jimlar cholesterol 7.4 mmol / l, statin far da kuma cimma wani matakin na 5.4 mmol / L muhimmanci rage hadarin m zuciya da jijiyoyin jini faru by 40% a kan gaba shekaru 5. A dama sauran karatu sun nuna cewa ragewan total cholesterol matakin kawai by 1 mmol / L da biyar rage alama na jijiyoyin zuciya thrombosis kuma inganta ciwon zuciya ko bugun jini.

Idan akai la'akari da statins, da ribobi da fursunoni na wanda yake magana da yawa na kwararru da kuma marasa lafiya, ba za mu iya fahimta da wadannan facts: za ka iya rubũta kwayoyi a farkon shekaru 40 da mazan, da kuma rage kasada na cututtukan zuciya - wani m dabara na tsawaita rayuwa. Kuma tun statins farashin ne quite m, wadannan kwayoyi sun tabbatar da tasiri, za a iya dauka ba tare da nuna bambanci zuwa da kansa kasafin kudin. Hakika, da latest ƙarni na statins ne yafi tsada, ko da yake wannan "Rosuvastatin" A ka'ida, shi ne quite tsada ga mãsu haƙuri. Kuma shi ne mafi m form shiri "Merten".

Comparative halaye: ribobi da fursunoni

Kimantawa statins, ga kuma da su yi magana sosai kawai. Muhawara "for" ne wani alama na da warkewa mataki: rage jini cholesterol kuma low-yawa kasarun adadi, hana hadarin m events da kuma taimako a cikin su magani. Duk da haka, kwayoyi kamar statins, akwai kuma contraindications. Akwai illa, lũra muhawara a kan aikace-aikacen.

Lokacin da far da statins hadarin myopathy. Ya yiwuwa sulhu tsakani da hanawa na kira na cholesterol, wanda ake bukata tsokoki. A mita na wannan sakamako ne musamman low, ko da yake da shi ya karu da coadministration tare da sauran hypolipidemic jamiái. Akwai kuma wani hadarin hanta ciwon daji Pathology, ko da yake yiwuwar irin wannan cuta, kamar yadda aka nuna ta hanyar kwanan nan karatu, musamman low. A daidai wannan tabbatar da da cewa da ciwon daji aka tsokane ta wasu dalilai. Saboda haka, a cikin shirye-shirye na "statins" contraindications kamata hana co-gwamnati na wadannan kwayoyi da sauran jamiái da inganta wani karu a maida hankali mai Kwayoyin.

The kudin na latest ƙarni na statins

A cikin latest ƙarni na statins daban-daban farashin, ko da yake su effects suke da daraja biya. Wani tambaya ne kawai da cewa sakamakon ayyukansu za a iya cimma tare da yin amfani da rahusa analogues aji ƙarnõnin farko. A musamman, ya fi na kowa statin Generation IV "Rosuvastatin" Farashin ne kamar yadda haka:

• 600 rubles domin Allunan na 40 MG.
• 400-450 a kan kwamfutar hannu 20 MG.
• 300-350 for 10 MG Allunan,
• 200 rubles 5 MG.

A kunshin ƙunshi 30 Allunan, isa ga daya ga watan na magani, yayin da wata-wata magani "pitavastatin" farashin su ne kamar yadda haka:

• 1 MG Allunan kudin game 700-750 rubles.
• Tablet 2 MG - game da 1000 rubles.
• kwamfutar hannu 4 MG - game da 1500 rubles.

A zabi tsakanin "Pitavastinom" da "rosuvastatin" dogara ne a kan hudu sharudda: farashin factor, da kudi na rage low-yawa lipoprotein, high-yawa lipoprotein karuwa cikar, tsaro. The gudun ragewan cholesterol da kuma kara HDL, kazalika da mafi kyau farashin dubi "Rosuvastatin", yayin da rubuce more amintacce ne "pitavastatin."

Karshe har sau biyu kamar yadda tsada a kwatanta da "rosuvastatin". Duk da haka, akwai yiwuwar yin amfani da wasu, mai rahusa statins. A mafi tattalin arziki m kasance a baya "Simvastatin". Yanzu ya aka maye gurbinsu "Atorvastatin", wanda aka kai a kai maye gurbinsu "rosuvastatin" (da darajar za dole fada). Kuma idan statins latest tsara farashin su ne unaffordable ga marasa lafiya, wajibi ne a yi la'akari da yiwuwar zalunta "atorvastatin" ko "Simvastatin". Af, mafi nazarin da "atorvastatin".

Muhawara a cikin ni'imar statins tsofaffi

A baya can, clinicians ne m rubũta statins ga marasa lafiya girmi 75 years. A sabili da wadannan dalilai:

• liyafar, da dama wasu azuzuwan da kwayoyi.
• juna rashin so ka kara wani aji na magunguna.
• rashin ko low komplaentnost magani.
• da rashin so da marasa lafiya saya da kansu statins da kuma yin amfani da su saboda rashin fahimtar su effects.

A yawan karatu da za'ayi tare da "Simvastatin" "Pravastatin" da "atorvastatin" nuna wani gagarumin karu a mace-mace a cikin marasa lafiya girmi 75 years. Bugu da ƙari, cikin karu a mace-mace da aka ma fi da cewa da marasa lafiya a cikin shekaru kungiyoyin 55-65 da kuma 65-75 shekaru. Saboda for kwayoyi na wannan aji (statins) comments daga masana a fili ya tabbatar da wani al'amari.

Wadannan magunguna iya dauka daga baya a rayuwa ko da kuwa ko akwai da m zuciya da jijiyoyin jini cuta. Kuma marasa lafiya da suke gaske da muhimmanci al'amurran da suka shafi don rage hadarin mutuwar daga tsokar zuciya infarction ko bugun jini, kana bukatar ka fahimci cewa idan da miyagun ƙwayoyi ne tasiri da kuma lafiya, shi ne shakka daraja shan. Musamman cewa magani da statins ya zama mafi m, kuma zai ci gaba kamar yadda irin wannan.

Features sake dubawa a kan latest ƙarni na statins

Marasa lafiya comments a kimantawa da ingancin wani musamman Generic statins ba nuni, domin ba su ji da muhimmanci canje-canje daga shan kwayoyi. Inganta jini sia profile ba ya bayyana a kan jihar kiwon lafiya da kuma ba shi da wani waje bayyanar cututtuka. Yana gane kawai sia profile. Saboda a lokacin da kimantawa statin cikin hikima shiryar da nazari masana. Kuma game da shirye-shirye a cikin abin da aiki sashi ne pitavastatin, kwararu na gida ba zai iya amsa.

A asibiti yi a cikin CIS "pitavastatin" saboda high kudin da saboda kasancewar "rosuvastatin" da kuma ta generics ba tambaya. A shirye-shirye "rosuvastatin", wanda aka nuna a bisa, da sauri mataki: sia profile bisa al'ada 1-2 watanni. The "atorvastatin" shi ne lokacin da rabi sau more. Har ila yau Generic "rosuvastatin" mafi aminci, tun biyu nau'in metabolized da cytochrome. A lokacin, wannan bayanai da aka dauka daga comments na masana, shi taka wata muhimmiyar rawa a zabi na statin a takamaiman asibiti yanayi.

A general karshe na latest ƙarnõni na statins

Kwayoyi "pitavastatin" da "Rosuvastatin" ne mafi m daga cikin wakilan da statin aji, ga wanda babban jiki na shaida tattara. Su effects ne kullum kamar irin waɗanda na "atorvastatin", amma akwai bambance-bambance. "Pitavastatin" da "Rosuvastatin" ba da damar isa manufa matakan cholesterol, da kuma low yawa lipoprotein a wani ƙananan sashi fiye da "atorvastatin".

Bugu da kari zuwa sama magabaci statins latest ne tsara muhimmanci da kuma shi ne wani al'amari. Wato, a lura da "pitavastatin" da "rosuvastatin" yi azumi daidaita jini lipids da kuma kawar homocysteinemia. Wannan yana da muhimmanci, kamar yadda batun na m jijiyoyin zuciya cuta, da kuma a cikin marasa lafiya da na kullum jijiyoyin zuciya cuta, jawo da jijiyoyin zuciya atherosclerosis. Tsaro na yin amfani da statins fi kardioform acetylsalicylic acid. Duk da haka, gaban contraindications ya haramta su yi amfani da wasu haƙuri yawan (ga. Janar contraindications).

halitta misalai

Magunguna dauke da "Rosuvastatin" samuwa a karkashin wadannan cinikayya sunayen: "AKORT", "Rozistark", "Rozukard", "Rozart", "Merten", "Rozulip", "Roxer", "Rustor", "Tevastor". Duk wadannan kwayoyi ne Generic "Crestor" wanda ya zama na farko rosuvastatin. Drug, cikinsa da aiki abu ne pitavastatin, rajista a matsayin «Livalo». Its generics suna «Pitavas» da kuma «Pivasta». ba su da faruwa a cikin CIS, ko da yake rajista a cikin Pharmacopoeia.

summary

A daidai da aji na kwayoyi effects da kuma bincike na da tasiri na amfani, da yin amfani da statins aka bashi garanti tabbatar da dorewar atherosclerotic plaque da kuma hana ta iri. Suna kuma amfani da su rage tsanani da atherosclerosis, shafi na sia profile na jini magani. A sakamakon haka, wannan aji na kwayoyi ne, haƙĩƙa, dole a cardiology. Kuma ingancin da latest ƙarni statins ne riga tasiri wajen rigakafin m jijiyoyin zuciya thrombosis.