Fibrates - abin da yake da shi? A abun da ke ciki, amfani, contraindications

An sani cewa zuciya da jijiyoyin jini cututtuka ne daga cikin mafi kowa pathologies a duniya. Kusan kowace tsofaffi mutum ne yake shan wahala hauhawar jini da kuma angina. Mutane da yawa suna da tarihin tsanani haifa cututtuka, kamar tsokar zuciya infarction da cerebrovascular hatsari. Shi ne a halin yanzu a tabbatar ta hanyar kimiya da cewa cututtukan zuciya da aka kai tsaye alaka dyslipidemia. Wannan matsayi yakan haifar da wani canji a cikin abun ciki na cholesterol, kuma m acid a cikin jini. Don normalize sia balance, marasa lafiya amfani statins da fibrates. Wannan kungiyar da kwayoyi da ake bukata a cikin dukan marasa lafiya da suka samu don kara cholesterol a cikin jini, ko da jinsi da shekaru.

Fibrates - abin da yake da shi da kuma abin da suke amfani da

An sani cewa da magani daga atherosclerosis ba zai yiwu ba tare da yin amfani da statins. Suna wajabta wa duk marasa lafiya da suke da hali to kiba, jijiyoyin zuciya da cututtukan zuciya, thrombosis. Bugu da kari ga statins, akwai wani rukuni na shirye-shirye - fibrates. Su inji na mataki ne dan kadan daban-daban. Saboda haka, wadannan kwayoyi wajabta ta ba yana nufin duk. Su fibric acid Kalam. Babban inji na mataki - da gyara na sia metabolism a cikin jiki. Fibrates - abin da yake da shi da kuma abin da su ga? Ta hanyar amfani da wadannan shirye-shirye nuna wani gagarumin raguwa a jini triglycerides. Babban inji na mataki na fibrates a kan gaskiyar cewa sun kunna enzyme - lipoprotein lipase, game da shi mugun gudu up da metabolism na fats. Watau shafar biochemical matakai abin da ke faruwa a cikin jiki. Bugu da kari ga gyara da dyslipidemia, fibrates da sauran effects. Daga cikin su - da yaki da free radicals, anti-kumburi da tonic sakamako. su ne ma anticoagulants.

alamomi fibrates

Saboda gaskiya cewa wadannan kwayoyi da yawa m effects, sunã da wani babban kewayon aikace-aikace. Babban nuni ga su nufi ne na rayuwa ciwo. Wannan yanayin ba wani m cuta, amma an dauke da manyan predisposing factor domin ci gaba da cututtuka na zuciya pathologies. A sharudda ga rayuwa ciwo:

1. Ciki kiba (kugu size karu da 90 cm kuma mafi girma).
2. High cholesterol a cikin jini gwajin.
3. Rage adadin high yawa lipoproteins.
4. Dagagge triglycerides kuma LDL.

A mafi yawan lokuta, da na rayuwa ciwo da aka hada tare da irin 2 ciwon sukari, wanda ya auku a cikin tsofaffi. Wadannan dalilai predispose ga ci gaban atherosclerosis, watau jari na lipids a cikin jijiyoyin bugun gini bango. Fibrates - abin da shi ne da kuma abin da manufar da suke gudanar? Bugu da kari ga na rayuwa ciwo, alamomi don amfani ne: hereditary siffofin dyslipidemia, kuma hypertriglyceridemia. Suna kuma nuna a marasa lafiya tare da wani tarihi na ciwon sukari da kuma gout.

A karkashin abin da yanayi fibrates suna contraindicated

Duk da cewa fibrates da yawan abũbuwan amfãni idan aka kwatanta da sauran kwayoyi su runtse cholesterol (statins), su za a iya amfani da su a cikin dukan marasa lafiya. Ka tuna cewa wadannan kwayoyi shafar metabolism, don haka amfani da su tsananin haramta a wasu jihohi. Fibrates da contraindications ga yin amfani da wadannan:

1. Pregnancy da nono-ciyar.
2. cutar hanta. Wannan contraindication saboda gaskiyar cewa wannan kungiya da kwayoyi shafar metabolism na m acid. A hanta cirrhosis da giya gepatoze aikin da jiki muhimmanci damuwa. Saboda wannan dalili, fibrates iya haifar da irin wannan marasa lafiya mai tsanani sakamakon, har zuwa hanta gazawar.
3. Calculous cholecystitis. Daya daga cikin sakamakon daga fibrates ne don karfafa lithogenicity, wato, da samuwar gallstones.
4. Kullum na koda gazawar. Fibrates kara da matakin na creatinine a cikin jini. Saboda haka, za su iya tsananta kullum na koda gazawar.
5. Kariya kamata a wajabta fibrates rashin lafiya tsofaffi. Su yi amfani da shi ne a ke so ga mutanen da fama da kullum shan barasa.

Side effects na fibrates

Fibrates - abin da yake da shi da kuma abin da bã su da illa? Ya kamata a lura da cewa, sabanin sauran kwayoyi, wannan kungiyar da kwayoyi da aka sosai da wuya ya haddasa rashin lafiyan dauki. Suna iya haka a yi amfani a cikin marasa lafiya da wani tarihi na amya, hay zazzabi, da sauransu. D. Duk da haka, fibrates da dama sauran illa. Mafi na kowa ne tashin zuciya da kuma amai, flatulence, ciki distension. Su kuma iya shafar juyayi tsarin. A wasu lokuta, sa ciwon kai, rashin barci da kuma ciki. Side effects suna dauke da canje-canje a cikin biochemical bincike na jini: ƙãra creatinine, Alt, AST. A cikin rashi na kullum na koda cutar da kuma hanta ne ba m ga haƙuri da kiwon lafiya.

Abin da magunguna ne fibrates kungiyar?

Don kwanan wata, akwai game da 10 iri na wannan kungiyar da kwayoyi. Don fibrate kwayoyi sun hada da: "Clofibrate", "bezafibrate", "Gemfibrozil" da "Fenofibrate". Kowace daga cikin wadannan shirye-shirye bambanta bisa ga yawan illa da kuma sashi. Allunan "Clofibrate" da aka sani shekaru da yawa da kuma yanzu da wuya amfani. Duk wani high dace, sau da yawa suka sa illa kamar cuta na narkewa kamar fili, zafi a cikin tsokoki (myositis), mallaka high lithogenic. Shi ne kasa mai guba miyagun ƙwayoyi "bezafibrate". Ya kasance ba a matsayin tasiri kamar yadda kuma sauri excreted daga jiki. Allunan "Gemfibrozil" ba da shawarar don amfani saboda da yawa illa (amma kasa da a cikin aikace-aikace na medicament "Clofibrate"). Har ila yau, saboda da bukatar dogon lokacin da amfani da kuma high allurai. Mafi zamani wakilin wannan kungiya ne da miyagun ƙwayoyi "Fenofibrate". Yana yana high dace da kusan babu illa. Bugu da ƙari kuma, shi ne wajabta wa marasa lafiya da gout, tun da shi rage matakin uric acid.

Fibrates: umarnin don yin amfani da wadannan kwayoyi

Ta yaya da yawa, kuma a cikin abin da Dosages amfani da waɗannan magunguna dogara a kan abin da irin shirye-shiryen da aka nada da halartar likita. More sau da yawa fiye da ba su bukatar ci for game da wata daya (ko fiye) 2-3 Allunan a rana. Babban nuni - shi ne na rayuwa ciwo. Da cewa irin wannan marasa lafiya sau da yawa wajabta fibrates. Shirye-shirye bukatar da za a hade tare da ta dace abinci mai gina jiki da kuma amfani karkashin iko da sia. Allunan "Gemfibrozil" da aka yi amfani da 1-2 a rana sau minti 30 kafin abinci ga 'yan watanni. Su analogues ne magunguna "Gevilon" da "Normolit". Shiri "bezafibrate" samuwa a allunan 200 MG da aka dauka sau 2 a rana for wata guda. Kuma hada shi ne da wani analogue - medicament "Retard" dauke da 400 MG na aiki abu. Drug "Fenofibrate" yana 2 saki siffofin: Allunan, kuma ya nanoparticles. Suna bayar da mafi tasiri sha da kuma bioavailability amfani 1 lokaci a rana (200 MG) a matsayin 'yan watanni. Its analogs - wani magani "Traykor" da "Lipantil".

Fibrates: miyagun ƙwayoyi interactions

Kafin ka fara amfani da kwayoyi a cikin wannan kungiyar, ya kamata ka yi shãwara da your likita da kuma tunatar da ku abin da sauran magunguna ana amfani da su. Fibrates ba za a iya hade da nephrotoxic da hepatotoxic jamiái. A musamman, "Cyclosporin" miyagun ƙwayoyi. A amfani da fibrates ne ba kyawawa ga marasa lafiya shan anticoagulant "Warfarin". Har ila yau, wannan kungiyar da kwayoyi ya kamata ba za a hade tare da sauran dipolipidemicheskimi jamiái (statins). Tun da shi qara da alama na tasowa myositis.

Reviews na likitoci da marasa lafiya a kan fibrate

Mafi yawan marasa lafiya yin amfani da fibrates wajen, kamar yadda muka gani a karu a LDL cholesterol, triglycerides da cholesterol. Doctors bayar da shawarar wadannan kwayoyi ga dukan marasa lafiya da rayuwa ciwo saboda su high dace da m-bakan. The kawai drawback ne contraindication ga yin amfani da fibrates, wanda sukan samu a mazan marasa lafiya.