Cholinesterase hanawa: da amfani da pharmacological

An sani cewa juyayi tsarin yana da yawa synapses. Su zama dole domin watsa daga hasken dake fitowa. Wannan tsari ya shafi dama iri masu shiga tsakani. Daga gare su, - .., Acetylcholine, norepinephrine, Gaba, serotonin, da dai sauransu shiga tsakani (riwayar) da ake bukata domin canja wuri na sakonni tsakanin neurons. Bugu da ƙari, saboda su shi ne da za'ayi zumudi ko hanawa musculature. A daban-daban pathologies daga cikin juyayi tsarin neurotransmitters aikin iya keta. Wannan ya faru saboda atrophic da degenerative matakai a cikin kwakwalwa. A cikin wadannan lokuta, amfani da kwayoyi da ake bukata domin aga ko attenuating watsa sigina. By mai kama da pharmacological kungiyar ne cholinesterase hanawa. Suna amfani da myasthenia, neuritis, amyotrophic kaikaice sclerosis, Alzheimer ta cuta, tabin hankali pathologies.

Effect na cholinesterase hanawa

Cholinesterase hanawa - wani magani da cewa an yi amfani da ko'ina a ilimin tsarin jijiyoyi da kuma ilimin halin tababbu. Sun kasu kashi da dama kungiyoyin, wanda kowannensu yana da m, a wani batu. A mataki na wadannan kwayoyi aiki da tarewa cholinesterase. Wannan enzyme samuwa ne a duka biyu lafiya mutane da kuma wadanda fama da cututtuka daban-daban. Wajibi ne a rushe neurotransmitter - acetylcholine. A sakamakon da aikin watsawa kaskanta zuwa choline da acetic acid. A daban-daban pathologies daga cikin kwakwalwa bawo atrophy faruwa a hankali. A sakamakon haka, wasu Tsarin iya durkushe gaba daya, ciki har da cholinergic tsarin. Bayan kwakwalwa atrophy, wannan take kaiwa zuwa degenerative matakai na autoimmune, dauke da kwayar cutar, kwayar halitta. Saboda halakar da forebrain nuclei akwai wani pronounced rashin neurotransmitter - acetylcholine. Muddin yiwu ya kasance babu kasawa na abu, wajibi ne a yi aiki a kan enzyme cewa halakar da ita. Domin wannan dalili, da cholinesterase hanawa ake amfani. Godiya a gare su, neurotransmitter aiki na iya dage ga dama shekaru.

Cholinesterase hanawa: kwayoyi rarrabuwa

Akwai da dama iri anticholinesterase kwayoyi. Suna classified bisa ga pharmacological effects a kan enzyme. Wasu daga cikin su suna tarewa cholinesterase komowar, wasu - dan lokaci. Ware 3 kungiyoyin medicaments. Daga cikin su:

1. Reversible blockers. Wadannan cholinesterase hanawa aiki a kan postsynaptic yi sigina. Godiya a gare su, da enzyme ne dan lokaci katse. Wannan kungiyar hada acridines da piperidine.
2. Psevdoneobratimye cholinesterase blockers. Su inji na mataki ne a tare da onionovoy ɓangare na enzyme kwayoyin. Bugu da kari, su sami damar daura da acetylcholine rabe. Wadannan Properties ne a rukuni na carbamates.
3. Komowar hanawa na cholinesterase. Wannan kungiyar da kwayoyi da aka sani da organo-phosphates wajen. Wakilin wani medicament "Metrifonate".

A rukuni na acridines hada da "jirgin sama m" kwayoyi da kuma "Velnakrin". Wakilai carbamates - magunguna "rivastigmine", "Epistatigmin".

Alamomi ga yin amfani da cholinesterase hanawa

Cholinesterase hanawa ake amfani da su bi tsoka cututtuka na tsakiyar asalin, atrophy da degenerative kwakwalwa cuta. Bugu da kari, wasu magunguna suna samuwa a cikin nau'i na saukad. Suna amfani a dagagge intraocular matsa lamba - glaucoma. Kwayoyi da hana cholinesterase reversible, ya nuna domin lura da gigin-tsufa, sama ta cuta da kuma Alzheimer ta. Son shi ne ya ba piperidine kungiyar, tun da sun kasance zabe da kuma da m illa. A cikin 'yan shekarun nan, da alamomi na amfani da kwayoyi ya karu. Wannan shi ne saboda a mafi cikakken nazari na dũkiyõyinsu. Domin cututtuka a cikin abin da wajabta anticholinesterase kwayoyi hada myasthenia gravis, na hanji atony, murdede dystrophy, amyotrophic kaikaice sclerosis, inna da gabar jiki degenerative asalin. Komowar hanawa ake amfani da hali na guba.

Contraindications ga yin amfani da cholinesterase kwayoyi

Magunguna a cikin wannan kungiya ba a yi amfani da convulsive cuta, hyperkinesis na wani etiology. Suna kuma contraindicated a marasa lafiya tare da m zuciya rashin cin nasara, asma, thyrotoxicosis. Shi ne a ke so ya dauki anticholinesterases tare da concomitant ciki miki, enteritis. Magunguna ba nuna wa ciki da kuma lactating mata.

Cholinesterase hanawa: zabi na kwayoyi ga Alzheimer ta cutar

Alzheimer ta cutar - shi ne atrophic CNS, a cikin abin da akwai ɓacin hankali, hali cuta da gigin-tsufa. Masana kimiyya a duniya na kokarin samun maganin warkar da wannan cuta. A m da kuma matsakaici mai tsanani da cuta ne da miyagun ƙwayoyi na zabi "donepezil". Yana nufin wani reversible cholinesterase hanawa, yana da wani zabe sakamako. A magani amfani da manufar da pathogenetic far. Ya ba su iya warkar da haƙuri gaba daya, amma slows ci gaban Alzheimer ta cutar bayyanar cututtuka.