Alanine aminotransferase ya karu - da wata ãyã daga kumburi da degenerative matakai a gabobin

Saboda aminotransferase migrating daga NH2-kungiyoyin da γ-amino acid bayarwa ga Mai karɓar - α-amino acid ba tare da matsakaiciyar samuwar ammonium. Wato, da transamination (transamination: reversible canja wuri na amino kungiyoyin to keto acid) - wani tsari bude shahara Rasha masana kimiyya da kuma Kritsman Braunstein.

Amino acid (aspartic, glutamic da alanine) a lokacin transamination tuba a cikin m α-keto acid, wanda suke gyara na tricarboxylic acid sake zagayowar. A lokacin da hadawan abu da iskar shaka a Krebs sake zagayowar, su ne a tushen samar da makamashi.

Transamination yana da muhimmanci a bayar da da urea sake zagayowar aspartate.

Duk da cewa da transamination halayen iya fallasa da kuma aromatic amino acid: phenylalanine, tyrosine da tryptophan - mai amfani da aikace-aikacen cikin magani ya samu wani definition daga cikin ayyuka na aspartate da alanine aminotransferase. Wadannan enzymes suke shiga ko'ina a cikin tsokoki na jikin mutum.

Alanine aminotransferase ya karu a ja jini Kwayoyin da ta maida hankali ne sau shida mafi girma idan aka kwatanta da cewa a cikin jini magani. Cincirindo na enzyme da ake gyarawa a cikin hanta kyallen takarda.

Alanine aminotransferase na kullum ne ba iri daya ba ga jikin mutum kyallen takarda. Alal misali enzyme aiki a cardiac nama ne 7.1 (E * 10-3 g nama homogenate), a hanta - 44, kwarangwal tsoka - 4,8, koda - 19, saifa - 1.2, 0.7, da kuma huhu magani - 0,016. Data kasance hanyoyin domin tabbatar da dalilin da aminotransferase aiki a magani ne zuwa kashi biyu kungiyoyin: da Gacin ƙarshe na Abubuwan (colorimetric, ta amfani na al'ada, ba sanye take da zazzabi sarrafawa Cuvette photometric inji) da kuma sanadin motsi (spectrophotometric).

B6 ne na kowa bitamin a da dama abinci. Duk da haka, ya kamata a tuna da cewa, a lokacin dafa abinci tsari (thermal obrobka) da bitamin da aka hallaka. Pyridoxine ne cofactor a mafi enzymes. Taro pirodoksin-5-phosphate a cikin jini rage-rage tare da shekaru. Saboda haka, aiki da wannan enzyme ne alanine aminotransferase, rage a cikin mutane girmi 64 shekaru (game da 30%) bisa ga waɗanda shekaru 46-63 shekaru. A taro na bitamin B6 a cikin jini magani alanine aminotransferase haddasawa.

Don sanin ko aikin jiha na hanta ne sau da yawa gwada aminotransferase matakan a wani haƙuri ta jini. Wannan shi ne saboda da farko ya nuna gaskiyar cewa ya canjãwa a su aiki na faruwa da yawa fiye da sauran awon sigogi. Kawar (fita) daga cikin hanta enzymes a cikin jini ne mai nuni da cytolysis - cell hallaka ko rushewa daga su membrane permeability. A lokacin da nazarin da canje-canje a cikin ayyuka na enzymes muhimmanci kafa da wurin kawar. Kana bukatar ka sani su aiki a maikacin jini da kuma lafiya jiki, da subcellular sarrafawa da kuma metabolism. A enzyme taro - alanine ya karu, musamman ma a hanta Kwayoyin, saboda haka, ko da kadan lalacewar su tsokani wani karuwa a enzyme aiki a cikin jini. Ganin aiki na enzyme gane asali cututtuka na hanta (hepatitis, steatosis).

Alanine aminotransferase ya karu necrosis na hanta, kazalika da parenchymal hepatitis. A low taro na enzyme da aka rajista, a kullum hepatitis da dystrophy. Ya kamata a ce cewa wani karuwa a aminotransferase aiki a magani fara 3-8 kwanaki kafin farko na babban asibiti ãyõyin cuta, kuma ya kai a kalla a cikin farkon kwanaki na ci gaba da pathological tsari.

Saboda haka, alanine aminotransferase ya karu: cirrhosis na hanta, jaundice, hanta ciwon daji, tsokar zuciya infarction, dama zuciya rashin cin nasara, hypoxia, buga, myositis, myocarditis, steatosis, pancreatin, na kullum shan barasa.