T-cell lymphomas: iri, cututtuka, ganewar asali, magani da kuma hangen nesa

T-cell lymphomas mafi sau da yawa bincikar lafiya a marasa lafiya a cikin tsufa, amma matasa da kuma yara ne ma yiwuwa ga cuta. Kuma maza sha daga gare shi fiye da sau da yawa fiye da mata.

Mene ne a T-cell lymphomas

Lymphoma - wani m rauni lymphoid nama da kuma sauran gabobin. A cikin hali na T-cell lymphoma, cutar rinjayar da fata da kuma Lymph nodes (ie ne epidermotropny hali). Ainihin abubuwan da cewa suna da hannu a cikin abin da ya faru na neoplasms ne T-lymphocytes (Kwayoyin cewa kullum samar da isasshen rigakafi martani). T-cell lymphoma (hoto wakilci a kasa) za a iya kafa a sakamakon jari na pathological nama salula abubuwa.

Sanadin da kuma karin dalilai

• gadar hali
• Immunodeficiencies.
• Tsawo daukan hotuna zuwa m dalilai: UV radiation, m sinadaran jamiái.
• Age al'amari (tsofaffi da marasa lafiya).
• A gaban ƙwayoyin cuta a cikin kwayoyin (HIV, Epstein-Barr, hepatitis C, B, T-lymphocyte virus), hanji cuta.
• A gaban maye gurbi a cikin tsarin na rigakafi, sashin jiki da kuma nama dasawa, immunosuppressive far saduwa.

Duk wadannan abubuwan iya aggravated ta (da bi, tsokane ci gaban da cutar), danniya, tamowa, juyayi da overloads, gazawar cika da gwamnatin sauran kuma aiki.

rarrabuwa

• T-cell lymphoma fata. Similar lymphomas yakan ci gaba a sakamakon daban-daban maye gurbi na T lymphocytes, abu don wani uncontrolled multiplication na karshen kuma, sakamakon haka, ana aiwatar da su a cikin wani Layer na epidermis. Halin da aiki nau'i na polymorph rash aukuwa lymphomas (plaque, marurai, stains, blisters). Kuma na farko da marasa lafiya koka da ya faru na scaly ko itchy spots, ƙarshe ta hanyar mayar da zuwa plaques, kuma baya a cikin ƙari foci.
• Gefe T-cell lymphoma. Wannan ra'ayi ya hada da dukan lymphomas da suke T-cell ko NK-cell asalin (sai neoplasm na m T-Kwayoyin da T-lymphoblastic cutar sankarar bargo). Popular sau da yawa, wadannan lymphomas faruwa tare da jini raunuka, fata, bargo da kuma kayan ciki, da kuma a cikin Lymph nodes, yaxuwa infiltrative canje-canje kiyaye.
• Angioimmunoblastic T-cell lymphoma. Yana bayyana a matsayin sealing lymphoid nama (a lokacin histological jarrabawa na Lymph nodes) immunoblast da jini Kwayoyin, tare da m cikakken canji na da tsarin da kuma samuwar mahaukaci jini.
• T-cell lymphoblastic lymphoma. Novobrazovanie, wanda dogara ne a kan munanan na T Kwayoyin. T Kwayoyin ba girma, su tsakiya zama fi'ilan jifa-jifa a cikin siffar, su da sauri da kuma ba dama fada. Ci karo da irin wannan lymphoma ne rare. Idan ka fuskanci irin wannan abin kwaikwaya bambanci ganewar asali da m cutar sankarar bargo.
• Non-Hodgkin ta T-cell lymphoma. Yana wakiltar wani babban rukuni na marurai cewa an hada da balagagge T-lymphocytes da kuma ba da lãbãri a gare Hodgkin ta cuta (Ina nufin, Hodgkin ta cutar). Na ga wannan kungiya suna ƙaddara da histological jarrabawa (tare da chlamydia a Shiri gano takamaiman salula abubuwa Berezovsky-Sternberg a ba Hodgkin ta lymphomas ne m).

raya ci gaban mataki

1. Da shan kashi na daya Lymph kumburi.
2. A baza na ƙari zuwa biyu Lymph nodes cewa suna located a gefe daya daga cikin diaphragm.
3. Mahara Lymph Tsarin a garesu na diaphragm.
4. Lymph nodes da kayan ciki, gaban metastases a kodan, bargo, hanta ko gabobin na gastrointestinal fili.

Janar cututtuka

A gaban ko babu wani asibiti manifestations dogara a kan irin ciwon daji da kuma wurinta. Duk da haka, akwai cututtuka da cewa ne muhimmi a kusan duk T-cell lymphoma:

• Sweating da dare.
• Rapid nauyi asara ne groundless.
• Mycosis fungoides.
• Low-sa yi a yanayin jiki.
• M gajiya da kula.

mycosis fungoides

Mycosis fungoides - daya daga cikin mafi m manifestations cewa faye hali T-cell lymphoma. An samu a saba'in cikin dari na marasa lafiya da wannan cuta, kuma yana da siffofi uku: gargajiya, decapitated da erythrodermic.

Gargajiya mycosis fungoides wuce ta wurin uku, saukarwa na ci gaba:

• Erythematous - daga asibiti cututtuka kama da psoriasis, eczema da sauransu. Marasa lafiya bayar da rahoton gaban stains m ko madauwari siffar, tare da kaifafan gefuna, na daban-daban masu girma dabam, tare da ruwan hoda-Violet launi da kuma scaly surface. Irin wannan abubuwa suna sau da yawa located a kan fuska da jiki, hankali da kara a yawa da kuma wucewa da sauran rabo. Irin wannan raunuka ba su karɓa magani da kuma ba za a iya gudanar da na dogon lokaci, ko ba zato ba tsammani bace. Bugu da ƙari, stains za a iya hade tare itching, wanda ba a tsaya ta al'ada wajen.
• Prakiraan infiltrative - auku bayan 'yan shekaru na farko. A wuri na sama stains plaques tare da wani m, taso ko nepravilnymi amma bayyanannu iyakoki, da shunayya da peeling a farfajiya. A site na rasa plaques ne yankunan ruwan kasa ko fata atrophy. Itching ƙaruwa, ya zama numfashi ba. Akwai m nauyi asara da kuma zazzabi, lymphadenopathy iya zama ba.
• Ƙari - on-site ko plaques a kan fata a can ba a canza bayyanar m ja da rawaya m ƙari nau'i mai siffar zobe ko dan kadan flattened siffar, kama wani naman kaza hat. A diamita irin wannan tsarin jeri daga daya zuwa ashirin millimeters, da kuma yawan iya zama daban-daban. Lokacin da ƙari an hallaka, m ulcers kafa a wurinsa, da zurfin wanda za a iya isa ga fascia ko kashi. Mafi sau da yawa rinjayar da baƙin ciki, Lymph nodes, huhu da kuma hanta. Narostaet, abin mãye da rauni. Marasa lafiya mutu daga zuciya rashin cin nasara, amyloidosis, ciwon huhu.

Eritrodermicheskoy nau'i ne halin da zargin narostaet m itching, redness da kumburi, da bayyanar confluent erythematous-squamous spots, hyperkeratosis na soles da itãcen dabĩnai, kazalika da gashi hasara. Kara girma duk Lymph nodes a cikin axillary, inguinal, femoral da cubital yankunan. Lokacin da aka same su plotnoelastichnye m palpation Lymph fakitoci ba soldered zuwa da kewaye kyallen takarda (fata). Lihodradka kiyaye (har zuwa 39 digiri), nauyi asara, rika zufa da dare da kuma gajiya. Mutuwa sakamako ne zai yiwu a lokacin da shiga exacerbating, abin mãye da zuciya rashin cin nasara.

A gaban decapitated nau'i a kan lafiya fata akwai mahara plaques, ƙarshe nemowa m harater. Mutuwa ta auku a cikin marasa lafiya a cikin shekara.

Clinical manifestations cutaneous lymphomas

T-cell lymphoma na fata sau da yawa yakan faru a kan backdrop na dogon-data kasance da kuma rashin iya lura da dermatological cututtuka. Tsokane da ya faru iya herpes ƙwayoyin cuta, radiation, kunar rana a jiki da sauransu. Similar lymphomas faruwa a matakai biyu: na farko (tsari ne sarrafa a cikin dermis), na biyu (a lokacin da fata raunuka ne sakamakon lymphocyte infiltration na ciki gabobin).

Babban cututtuka su ne:

• Polymorphic fata kurji.
• Tashin itching.
• A gaban kananan, lebur abubuwa a nodular form.
• Bayyanar yellowish plaques, baya ta hanyar mayar da cikin Aljihuna na hyperpigmentation da atrophy (idan plaque form).
• The asibiti hoto kama psoriasis (a melkouzelkovoy irin).
• Rashin ruwa, kumburi, redness da peeling da fata (tare da erythrodermic irin cuta).

Symptomatology na gefe lymphomas

Clinic cuta dogara a kan mataki da kuma irin pathological tsari.

Halin da wata karuwa da lymphoid nama a cikin wuyansa, makwancin gwaiwa da axillary yankuna.

Marasa lafiya koka wuce kima sweating, mai tsanani nauyi asara, rashin ci, janar wani rauni, zazzabi, da kuma a gaban an kara girman baƙin ciki, kuma hanta (wanda yake shi ne quite na kowa) - by shortness na numfashi, maimaita tari da kuma ji na wani nauyi a cikin ciki.

bincikowa da

• Dubawa, tarin gunaguni da anamnesis oncologist.
• Janar jini da fitsari bincike.
• Jini Biochemistry, kazalika da gwajin don antibodies da hepatitis ƙwayoyin cuta.
• A biopsy na lalace Lymph kumburi (wanda ba ka damar tabbatar da ganewar asali T-cell lymphoma).
• Amurka.
• MR.
• CT.
• Onkoskrining jiki.
• Immunofenotipirovannoe binciken.
• Kwayoyin kayyade ƙididdiga.
• Cytogenetic analysis.

far

Jiyya na T-cell lymphoma dogara a kan tsari da kuma mataki na aiwatar.

Alal misali, ga erythematous mataki mycosis fungoides musamman anticancer far ba ambatacce, kuma da matsanancin corticosteroids da interferon da ake amfani.

A anti-ƙari magani ne a gudanar da jiyyar cutar sankara da kuma radiotherapy.

A daidai da wani nau'i na cutar (indolent, m, da kuma sosai m) ne m da tsawon da abun da ke ciki na magani, da kuma fi.

Indolent lymphoma ba a bi, amma kawai a kai a kai lura idan aiwatar progresses, da dabara canza.

A lura da m siffofin hade da yin amfani da tsoka kwayoyi da kuma Rituximab (monoclonal antibody).

Idan ya zo ga sosai m lymphomas, rubũta da kwayoyi da aka yi amfani da magani daga m leukemias.

Popular sau da yawa, jiyyar cutar sankara a hade tare da kara cell dasawa.

Duk da haka, mafi tasiri magani ga lymphoma ne da za su gudanar da wani talatin radiation far (kamar yadda aka bayyana a cikin Elekta Matsayi), da kuma bayan samun da tsoka jamiái.

Matsalolin samun tsoka jamiái iya sun hada da: huhu, da nono, da kuma sauransu. Radiation far iya wuya ta ci gaba da jijiyoyin zuciya atherosclerosis.

Bayan nasara magani ne wajibi fi.

T-cell lymphoma: forecast

• Lokacin dace ganewa na cutar (farko) da kuma aiki da isasshen magani biyar-shekara rayuwa kudi ne mutum tamanin da biyar cikin dari, da kuma ga yara da marasa lafiya - to casa'in cikin dari.
• Game da angioimmunoblastic lymphoma forecast m. A tsawon rayuwar jama'a a marasa lafiya tare da irin wannan ganewar asali ne kawai biyu da rabi - shekaru uku. A rayuwa kudi na kawai daya bisa uku na marasa lafiya da tsawon shekaru biyar.
• A gaban T-lymphoblastic form hangen nesa dogara a kan gaban / rashi na rauni daga cikin bargo. Idan bargo ba ya canzawa, sakamakon ne yawanci m. In ba haka ba, da kyautata a kawai ashirin cikin dari na marasa lafiya za a iya sa ran.
• Hangen nesa da kuma rayuwa naman kaza avium dogara a kan tsari da kuma mataki na aiwatar. Saboda haka, a lokacin da rayuwa mashaya fom - har zuwa shekaru goma, da kuma wani unfavorable hangen nesa a cikin hali na Accession na ciwon huhu, da kuma sauransu. eritrodermicheskoy form sorovozhdaetsya shiga daban-daban da rikitarwa sakamakon mutuwa ya auku a cikin biyu - da shekaru biyar. yayin da headless nau'i na wani matalauci hangen nesa, mutuwa ya auku a cikin shekara.