"Methotrexate" a rheumatoid amosanin gabbai: reviews. Umarnin don amfani, bayanin irin shirye-shiryen da

Rheumatoid amosanin gabbai, idan fassara zahiri shi tare da Girkanci, tana nufin wani Jihar kumburi. Tambayar da abin da abubuwan tsokana da ci gaban da wannan cuta ne har yanzu ba tãtacce. Kaikaitaccen bayanai da ƙara yawan leukocytes a cikin jini, kuma Ya ƙãra erythrocyte sedimentation kudi (ESR), ya sa ya yiwu don kammala da cewa, aiwatar da bunkasa cutar ne m yanayi. An yi imani da cewa impetus ga ci gaban da cuta ne kamuwa da cuta, har suka sa disturbances a cikin aiki na rigakafi da tsarin. Duk da haka, batun wannan, ba duka amma kawai waɗanda ke da wata iyali tarihi. A sakamakon gabatar da kamuwa da cuta a cikin jikin mutum shi ne samuwar rigakafi gidaje (daga ƙwayoyin cuta, antibodies, da sauransu. P.), wanda tara a cikin tsokoki da kuma haifar da hadin gwiwa lalacewa.

A mafi yawan lokuta, magani na wannan mummunan cuta ne zafi alleviating, inda hakan ya kwarara da cutar tsari da tanadi da lalacewar (as shi ne zai yiwu a kowane hali) ta amfani da m hanyoyin.

Kwayoyi domin lura a halin yanzu akwai a yalwace. Daya daga wadannan shine "Methotrexate". A rheumatoid amosanin gabbai (reviews na ma'aikatan kiwon lafiya, da kuma marasa lafiya tabbatar da wannan bayanai) ya ce medicament ne tasiri isa, sakamakon da tasiri za a ji na dogon lokaci.

Abun da ke ciki da kuma aiki

Babban aiki sashi daga cikin miyagun ƙwayoyi ne methotrexate. Wannan nitostatik, wani antagonist na folic acid. A halin yanzu, domin inda hakan da ci gaban rheumatoid amosanin gabbai magani aiwatar "methotrexate" da ake amfani da mafi sau da yawa fiye da wasu hanyoyin. A ainihi wannan ne antitumor miyagun ƙwayoyi, a cytostatic wakili, damuarn mitosis (cell division tsaye ba) damuarn ci gaban da rayayye proliferating kyallen takarda, damuarn cin gaban siffofin maruran.

Bisa kididdigar da, da tasiri na da miyagun ƙwayoyi ne lura a 80% da marasa lafiya, mai kyau Trend ne m bayan 2-6 makonni bayan fara far. Bayan dogon lokaci na magani (har zuwa 5 years) far "Metotraksatom" soke yawa kasa da wani sauran magunguna amfani da su rage cin gaban rheumatoid amosanin gabbai.

Saki nau'i na da miyagun ƙwayoyi

Kai magani ne Rasha m na Austria "Methotrexate Ebewe". The asali miyagun ƙwayoyi manufacturer offers da abokan ciniki a dama daban-daban siffofin samar. Allunan ne kudi ne samuwa a cikin uku dosages na 2.5 MG, 5 MG da 10 MG na babban aiki bangaren. Dukan su suna cushe a propylene vials na 50 guda kowane. Bugu da kari, "Methotrexate" (Austria - manufacturer) za a iya saya a kashi na 50 MG / 5 ml a cikin wani bayani ga allura. Ampoules sanya daga duhu gilashi kuma cushe a cikin wani kwali akwatin.

Shi ne kuma zai yiwu in saya medicament a cikin wani nau'i na tattara da shiri na infusions (droppers). Sashi - 100 MG / 1 ml. A irin wannan nau'i, "Methotrexate" da aka sayar a vials na 5, 10, 50 ml. A wani kwali akwatin cushe daya vial.

Alamomi ga samun "methotrexate"

Alamomi ga yin amfani da miyagun ƙwayoyi ne quite musamman, tun bayan da babban manufar - yaki da siffofin maruran. An shawarar daukar "Methotrexate" a lokuta inda haƙuri yana fama da m lymphoblastic cutar sankarar bargo da kuma lymphomas nehodzhinskimi. Har ila yau, an wajabta, a trophoblast marurai naman kaza mycosis da psoriasis (a cikin tsanani, saukarwa).

Har ila yau, idan wasu hanyoyin kwantar da hankali da kuma kwayoyi ba su da wani tasiri appreciable amfani "MTX" for rheumatoid amosanin gabbai. Reviews rheumatologists masana kan magunguna wajen tabbatacce.

Alamomi ga liyafar na "Methotrexate Ebewe" da ɗan fi girma. Kwararru rubũta shi a lokacin da haƙuri malignancies daban-daban da kuma tsarin gabobin: huhu ciwon daji da kuma nono, osteosarcoma da kuma taushi nama sarcomas, testicular da ovarian marurai, Kaposi Jung, retinoblastoma da autoimmune cututtuka.

Wa ya kamata ba kai da magani?

Yana da unacceptable dauki wani magani ga mutane da hypersensitivity da babban aiki sashi. Contraindicated liyafar "methotrexate" mata masu ciki da masu shayarwa da mums. Ba prescribers tare data kasance sabawa na hanta da kuma kodan, hematological cuta harafin (anemia, thrombocytopenia, leukopenia). Ba shi yiwuwa a fara jiyya magani ga marasa lafiya a cikin m lokaci na wani cutar, na rigakafi da kanjamau fama. Kamar yadda Rasha m, da kuma asali "Methotrexate" (Austria) ba a yarda ya bayar da 'ya'yansu har zuwa shekara uku.

Lokacin da wani yawan cututtuka da miyagun ƙwayoyi ne ba tare da taka tsantsan. Wadannan matsaloli sun hada da ciki ulcers da kuma 12 duodenal miki, ulcerative colitis, da kuma dehydration. A kwayar, fungal da kuma na kwayan cututtuka ma bukatar su yi aiki sosai matsa a hankali. Don wannan kungiyar ne al'amurran da suka shafi kafin radiotherapy, ko jiyyar cutar sankara.

Zai yiwu illa

"Methotrexate" a ampoules, Allunan, a lokacin da infusions iya haifar da wani yawan illa. Quite tsanani matsaloli zasu iya tashi daga hematopoietic tsarin (leukopenia, thrombocytopenia, da sauransu. P.) Kuma gastrointestinal (dyspepsia, anorexia, hanta yawan guba, pancreatitis). A juyayi tsarin iya amsa ciwon kai, drowsiness, paresis, seizures. High allurai da miyagun ƙwayoyi iya fararwa da ci gaban encephalopathy. Sabawa daga na gani gabobin da zuciya da jijiyoyin jini tsarin (hypotension, pericardial effusion, thromboembolism).

Iya ci gaba numfashi rashin cin nasara, na kullum obstructive na huhu cuta, shortness na numfashi, bushe, nonproductive tari, da zazzabi. Tare da genitourinary tsarin, akwai hadarin mai tsanani koda cuta ko koda gazawar. Zai yiwu rushewa daga spermatogenesis da oogenesis, rage libido, rashin haihuwa, rashin ƙarfi.

Idan mace da ciki, "Methotrexate" (injections, Allunan, drip) zai iya sa ashara, malformations ko fetal mutuwa.

Allunan dosing regimen

A lura da m neoplasms regimen na kwayoyi akayi daban-daban tsara da kuma shi ya dogara da kewaye jiyyar cutar sankara da akayi. Idan ya zo ga aikace-aikace na medicament "MTX" for rheumatoid amosanin gabbai (Patient martani da kyau hali), da farko kashi ne yawanci 7.5 MG sau ɗaya a mako. Za ka iya yi dukan kashi a lokaci daya, kuma ba za ka iya raba shi a cikin 3 allurai a 12 hour jinkiri.

A wasu lokuta (don cimma wani mafi kyau duka sakamako) mako-mako kashi iya karu. Duk da haka, ya kamata ba ƙetare 20 MG. Lokacin da ake so na asibiti sakamakon aka samu, da sashi ya kamata a hankali rage zuwa m. A mafi kyau duka tsawon magani shakka ba asibiti kamu.

Injections na "methotrexate"

Kuma yaya allura da miyagun ƙwayoyi "Methotrexate"? Injections for rheumatoid amosanin gabbai fara yin wani sashi na 7.5 MG da mako. Wannan za a iya yi subcutaneously, intramuscularly ko intravenously. Idan da miyagun ƙwayoyi da aka kyau jure da haƙuri, da kashi za a iya hankali ya karu mako-mako a 2.5 MG amma ba fiye da 25 MG. Lokacin da warkewa sakamako ne kai (yawanci 1-2 watanni bayan qaddamarwa magani), da kashi ya kamata a hankali rage ga m zama dole. Ga kowane haƙuri da rheumatoid amosanin gabbai, sashi iya hankali gyara domin mafi kyau duka sakamakon da magani. Clinical karatu sun nuna cewa "Methotrexate" mafi tunawa da ba kadan gefe martani, idan allura subcutaneously ko intramuscularly.

Tare da ci gaba da liyafar da "methotrexate" na farko m warkewa sakamako ci gaba na tsawon shekaru biyu. Idan ka soke rheumatoid amosanin gabbai miyagun ƙwayoyi yana da wani sakamako a 3-6 makonni.

wuce kima allurai

Wuce kima allurai Rasha medicament ko miyagun ƙwayoyi "Methotrexate Ebewe" (Allunan, injections, infusions) ba a nuna wani takamaiman bayyanar cututtuka. yawan abin sama al'amari na iya zama matakin methotrexate maida hankali a cikin jini jini.

Jiyya ne nan da nan (optimally a farko hour) na maganin guba aikace-aikace, wanda shi ne alli folinate. A girma daga injectate dole ne daidai ko mafi girma daga kashi samu "methotrexate". Ƙarin allurai na alli folinate iya wajabta ta likita kamar yadda ake bukata. Kafin ka shigar da kowace m kashi, sa'an nan kowane 6 hours a ko'ina cikin tsari ya kawar da cututtuka na wani yawan abin sama da yin amfani da maganin guba wajibi ne domin sanin da PH na fitsari. Irin matakan za su rage girman da alama na tasowa nephropathy.

Har ila yau a cikin kunshin matakan da ake bukata don kawar da tasirin da wani yawan abin sama na magani ya hada da hydration da fitsari alkalinization. Wadannan hanyoyin za bugun sama da excretion na methotrexate.

Hulda da sauran abubuwa da shirye-shirye

Idan wani haƙuri yana da gout, kuma da nada "Methotrexate" magunguna ko "Methotrexate Ebewe" kashi arthrifuge kwayoyi ya kamata a gyara. Lokaci guda amfani da salicylates, phenylbutazone, fenitoiona, sulfonamides, da dama wasu maganin rigakafi (tetracycline, penicillin, chloramphenicol), anticoagulants kaikaitaccen sakamako da kuma hypolipidemic magunguna iya kai ga tsanani yawan guba, ko da mutuwa.

Manyan yawa na "methotrexate" a layi daya tare da NSAIDs zai iya sa mutuwa daga m hematologic da gastrointestinal yawan guba. A hade da NSAIDs kuma low-kashi magani kafin mu iya rage tukar tumbi da karshen da na koda tubules.

Hepatotoxic kwayoyi (bisa sulfasalazine, azathioprine, ethanol) zuwa kara hadarin hepatotoxicity, gematotoksicheskim - gematotoksichnosti "methotrexate". Lokaci guda aikace-aikace na miyagun ƙwayoyi da kuma radiation far jiyya zai iya sa bargo ciki.

musamman umarnin

Kafin ka fara jiyya magani "Methotrexate" (allura, idan an zartar kwayoyi - ba kome), wajibi ne a gudanar da cikakken jini count (sanin matakin na platelets), Biochemistry (domin sanin dabi'u na hanta enzymes, albumin, bilirubin), yi kirji X-ray. Bugu da kari, shi ne zama dole don su bincika kodan, a wasu lokuta, ba za superfluous gwaje-gwaje domin hepatitis da kuma tarin fuka.

Domin ba miss a lokacin da maye, shi wajibi ne don sarrafa abun da ke ciki na gefe jini (yawan leukocytes da platelets), koda aiki, hanta transaminase aiki, matakin na uric acid a magani. Kafin kowane yin amfani da "methotrexate" baka mucosa da kuma pharynx kamata a bari for gaban ulcers. Kan aiwatar da bargo hematopoiesis kamata a bari a farkon far, da zarar lokacin da magani da kuma bayan ta ƙulli.

price kewayon

saki form (kwamfutar hannu, allura) da kuma kashi - babban dalilai shafi kudin da "Methotrexate" miyagun ƙwayoyi.

Price marufi da Allunan (50 inji mai kwakwalwa.) Tare da wani 2.5 MG kashi iya Range daga 240 zuwa 250 rubles. A wannan adadin 5 MG kashi Allunan za a iya saya don wani adadin na 390 to 420 rubles. Marufi da miyagun ƙwayoyi tare da mafi kashi (10 MG) zai kudin 530-550 rubles.

Da mafita ga allura ne yafi tsada, da kuma farashin yaduwar ne yawa fadi. Alal misali, 5 ampoules medicament tare da wani sashi na 50 MG / 5 ml a wasu Pharmacy iya kudin game 1200-1300 rubles, yayin da wasu - 4900 rubles.

mabukaci ra'ayi

Akwai duka tabbatacce kuma korau ra'ayoyi da marasa lafiya game da magunguna "Methotrexate". A rheumatoid amosanin gabbai, da sake dubawa kagaggun rubuta tabbatacce Trend (game da 80% da marasa lafiya samu inganci a farko 1-1.5 watanni magani). Duk da haka, wanda zai iya ji sau da yawa game da illar da miyagun ƙwayoyi a kan haƙuri, ci gaban illa mai sãɓãwar launukansa a mai tsanani a kan wani ɓangare na daban-daban da kuma tsarin gabobin.

Don rage girman mai mummunan tasiri, "Methotrexate" ya kamata a nada kawai da halartar likita, kuma ya ma yana wajen samar da wani magani da shirin da kuma zabi wani tasiri kashi.