Mene ne kadan buga sunadaran

Idan da yawan zafin jiki ta fito, kwayoyin halittar reacts zuwa wannan ta hanyar samar da wani irin mahadi, da aka sani da "kadan buga sunadarai". Saboda haka mutane da amsa, don haka da cat zai amsa, saboda haka wata dabba amsa, tun da shi ne hada da rai Kwayoyin. Duk da haka, ba kawai da karuwa a yawan zafin jiki triggers kira na zafi tura furotin na Chlamydia, da sauran jinsunan. Sau da yawa tsokane tsananin gajiya halin da ake ciki.

janar bayanai

Tun da zafi tura sunadarai na samar da jiki kawai a takamaiman yanayi, sun haifar da wata yawan bambance-bambance daga al'ada sadarwa. A lokacin da samuwar bambanta hanawa na magana da core gina jiki pool, wanda ke taka muhimmiyar rawa a metabolism.

HSP-70 eukaryotes, prokaryotes DnaK - shi ne irin wannan iyali, a cikin abin da masana kimiyya a hade zafi tura sunadaran da suke da muhimmanci ga rayuwa a salon salula matakin. Wannan yana nufin cewa godiya ga irin wannan mahadi da tantanin halitta zai iya ci gaba da aiki ko da a cikin yanayi inda danniya, zafi, m kafofin watsa labarai suna tsayayya da wannan. Duk da haka, wannan iyali sunadaran iya zama da hannu a cikin tafiya a gaba a cikin al'ada tafiyar matakai.

a kan wani microscopic matakin Biology

Idan domains ne m zuwa 100%, yayin da eukaryotes, prokaryotes fiye da 50% homologue. Masana kimiyya sun nuna cewa, yanayin duk gina jiki kungiyoyin ne 70 kDa HSP - daya daga cikin masu ra'ayin rikau. Sadaukar da wannan binciken da aka yi a shekarar 1988 da kuma 1993. Mai yiwuwa, ba za ka iya bayyana sabon abu ta hanyar wani chaperone aiki muhimmi zafi tura sunadarai a cikin kwayuka sunadaran.

Yaya ta yi aiki?

Idan muka yi la'akari da eukaryotes, a ƙarƙashin rinjayar zafi tura shigar da ya auku HSP genes. Idan wasu cell kauce masa stressful yanayi, sa'an nan akwai dalilai a tsakiya, cytoplasm kamar yadda monomers. Irin wannan fili ba muhimmi a cikin DNA nauyin aiki.

Tsira danniya yanayi, da cell behaves kamar haka: Hsp70 cleaved cewa qaga samar da denatured sunadaran. HSP suranta trimmers, aiki ta sauya hali da kuma shãfe na DNA, wadda take kaiwa ƙarshe da jari daga gyara a cikin cell tsakiya. A tsari yana tare da ci gaban da mahara kwafi chaperones. Hakika, wannan halin da ake ciki tsokane da nassi na lokaci, da kuma lokacin da ta faru, na Hsp70 iya sake haɗewa da HSP. Aiki hade tare da DNA, ya zo da kõme ba, tantanin halitta ya ci gaba da aiki kamar yadda idan babu abin da ya faru. Wannan jerin ya iya gane abin da ke faruwa a shekarar 1993 a nazarin da HSP gudanar Morimoto. Idan jiki ne buga da kwayoyin cuta na iya sa'an nan tattara a kan HSP synovium.

Kuma me ya sa?

Masana kimiyya sun iya bayyana cewa HSPs aka kafa a sakamakon rinjayar da dama korau, a kawo hadari ga rayuwa yanayi Kwayoyin. Danniya tareda žata tsoma daga waje zai iya zama musamman bambance bambancen, amma manyan zuwa wannan embodiment. Saboda HSP cell tsira a ƙarƙashin rinjayar m dalilai.

An sani cewa HSPs aka subdivided cikin uku iyalansu. Haka kuma, masana kimiyya sun gano cewa akwai antibodies da zafi tura gina jiki. A rabo a cikin kungiyoyin HSP sanya shan la'akari da kwayoyin nauyi. Uku Categories: 25, 70, 90 kDa. Idan a wani rai gabar yana da wani al'ada aiki cell, sa'an nan a cikin shi wani za a daban-daban sunadarai gauraye da juna, wajen kama. Saboda HSP denatured sunadaran da nada yadda ya kamata, na iya sake zama wani bayani. Duk da haka, ban da wannan aiki, akwai wasu sauransu.

Abin da muka sani, kuma abin da zai iya tsammani

Har yanzu, zafi tura furotin na chlamydia, kazalika da sauran HSP, ba a karatu gaba daya. Hakika, akwai wasu kungiyoyin sunadaran, wanda masana kimiyya da fairly manyan adadin bayanai, da kuma, akwai waɗanda suka yi tukuna don Master. Amma yanzu kimiyya ta kai wani matakin inda ilmi suka ce cewa a Oncology zafi tura gina jiki na iya zama da gaske amfani da kayan aiki, kyale lashe daya daga cikin cututtukan da ake tsoro na mu karni - ciwon daji.

A mafi girma adadin data masana kimiyya da game da HSP na Hsp70, iya shiga sadarwar da dama sunadarai, aggregates, gidaje, ko da mahaukaci. A tsawon lokaci, da saki ya auku, ya bi ta hanyar fili na ATP. Wannan yana nufin cewa da mafita a cikin cell da aka maimaita, da kuma sunadarai, na karshe daidai coagulation tsari na iya sake a hõre wannan aiki. Hydrolysis na fili ATP - sunadaran da cewa yin wannan zai yiwu.

Anomalies da kuma matsayin

Yana da wuya a overestimate rawar da rayayyun kwayoyin halitta don zafi tura sunadaran. Duk wani cell ko da yaushe ya ƙunshi mahaukaci sunadarai wanda taro zai iya tashi idan akwai waje zuwa wannan zaton. Da hankula labarin - shi ne zafi fiye da kima ko tasiri da kamuwa da cuta. Wannan yana nufin cewa domin ci gaba da cell aiki ne mai gaggawa bukatar samar da wani mafi girma adadin HSP. Kunna kwafi inji cewa qaga samar da sunadarai, mai cell adapts canza yanayi da kuma ci gaba da aiki. Duk da haka, tare da riga aka sani sunadaran, yawa zauna da za a gano. A musamman, irin wannan in mun gwada manyan filin na aiki domin masana kimiyya ne antibodies da zafi tura furotin na chlamydia.

HSP, a lokacin da polypeptide sarkar na karuwa ne, kuma sun sami kansu a cikin yanayi da cewa yin shi zai yiwu ya shiga tare da ita a dangane zai kawar nonspecific tari da kuma rage daraja. Maimakon haka, nadawa faruwa a al'ada aiki a lokacin da ake bukata chaperones suna da hannu a cikin tsari. Hsp70 ne m da ake buƙata a lokacin bayyanuwar polypeptide sarƙoƙi tare da sa hannu na Apr. Ta hanyar HSP za a iya cimma da cewa ba iyakacin duniya yankunan ma ta shafa enzymes.

HSP da kuma magani

A FMBA Rasha masana kimiyya sun iya haifar da wani sabon magani, yin amfani da shi don gina wani zafi tura gina jiki. A maganin cutar daji, ya gabatar bincike ma'aikatan, da ya shige na farko tabbaci a dakin gwaje-gwaje hakori kamu da sarcomas, melanomas. Wadannan gwaje-gwajen da sanya shi yiwuwa a ce tare da amincewa da cewa wani gagarumin mataki a gaba a yaki da cutar daji.

Masana kimiyya sun nuna, kuma sun kasance iya tabbatar da cewa da zafi tura gina jiki - wani magani, da kuma more musamman, na iya zama dalilin wani tasiri miyagun ƙwayoyi, sun fi mayar da godiya ga cewa wadannan kwayoyin an kafa a stressful yanayi. Tun da su Asali ana samar da jiki don tabbatar da cell rayuwa, da aka zaci cewa lokacin da ya dace hade tare da sauran kwayoyi za a iya sarrafawa ko da ƙari.

HSPs taimaka da miyagun ƙwayoyi da aka gano a cikin waxannan cututtukan kwayoyin cutar Kwayoyin da mu jimre wa da incorrectness na DNA a gare su. An yi imani da cewa wani sabon maganin zai zama daidai da tasiri ga wani subtype na m cututtuka. Yana sauti kamar hikaya, amma likitoci tafi har ma da kara - sun bayar da shawarar cewa wani magani zai zama samuwa a kowane mataki na da iri. Yarda, wani zafi tura furotin daga ciwon daji a lokacin da wuce duk gwaje-gwaje da kuma tabbatar da su AMINCI, zai zama wani invaluable kadara ga wayewar dan adam.

Gane asali da kuma yi wa

A mafi cikakken bayani game da bege na zamani magani ce Dr. Simbirtsev, daya daga waɗanda suka yi aiki wajen samar da miyagun ƙwayoyi. Daga cikin hirar da za a iya fahimta, da abin da dabaru masana kimiyya sun gina wani magani da kuma yadda shi ne ya kawo yadda ya dace. Bugu da kari, karshe za a iya kõma, akwai riga ya mai zafi tura gina jiki ko gwajinsu da aka basu fito ba.

Kamar yadda na ambata a baya, idan da kwayoyin ba tsira stressful yanayi, alhãli kuwa da samar da SB faruwa a musamman karamin girma, amma shi qara muhimmanci tare da canji na waje tasiri. A daidai wannan lokaci da al'ada jikin mutum ne iya nuna irin wannan yawan HSPs, wanda zai taimaka wa kashi bayyana malignancy. "Kuma abin da ya faru idan HSP daga waje?" - tunani da masana kimiyya suka yi wannan ra'ayin a matsayin dalilin da binciken.

Ta yaya ya kamata ya yi aiki?

Don ƙirƙirar sabon maganin, da masana kimiyya a cikin Lab ka sake abin da kuke bukatar zuwa rayuwa Kwayoyin fara nuna HSP. Don wannan da aka samu mutum gene cloning zaunanniya lokacin da yin amfani da kayayyakin zamani. A kwayoyin gwada a dakunan gwaje-gwaje, sun samo asali har ba tukuna fara samar da nasu coveted domin gina jiki masu bincike.

Masana kimiyya a kan tushen da bayani samu a cikin binciken kusantar da karshe a kan sakamako daga HSP a kan jikin mutum. Domin wannan shi ya wajaba don tsara da X-ray tsarin bincike na sunadaran. Make shi ne, ba sauki: ya zama dole a aika samfurori da kewayewa na duniya. Wannan shi ne saboda gaskiyar cewa duniya yanayi ne ba dace da daidai, uniform ci gaban lu'ulu'u. Amma da sarari yanayi da damar samar da daidai da waɗanda lu'ulu'u, wanda aka bukata don masana kimiyya. Bayan koma gidansu duniya gwaji samfurori da aka raba tsakanin Japan da kuma Rasha masana kimiyya suka dauki up su analysis, suka ce, ba tare da rasa wani biyu.

Kuma suka sãmi?

Duk da yake aiki a wannan yanki shi ne har yanzu a karkashin hanya. Wakilin wata kungiyar masana kimiyya ya bayyana cewa, ya yiwu don a san: babu wani daidai dangantaka tsakanin HSP kwayoyin da sashin jiki ko nama na halitta mai rai. Kuma ya ce game da universality. Saboda haka, idan wani zafi tura gina jiki, da kuma gano aikace-aikace a magani, zai zama wani da dama, kai tsaye daga babbar dama cututtuka - abin da sashin jiki ko aka buga malignancy, shi zai yiwu in warkar.

Da farko, masana kimiyya sun sanya wani magani a cikin ruwa tsari - Guinea gudanar injective. Kamar yadda na farko kofe don tabbatar da kudi da aka dauka berayen, beraye. Yana iya gane lokuta da waraka biyu na farko da daga baya, saukarwa da cutar. A halin yanzu mataki ne ake kira pre-gwajinsu. Masana kimiyya sun} iyasta lokacin da ta ƙarshe a kalla a shekara. Bayan da cewa za su zo daga gwajinsu. A cikin kasuwar na wani sabon wurin, yiwu a magani, zai kasance da samuwa ko da bayan 3-4 shekaru. Duk da haka, kamar yadda masu bincike lura, yana da gaske ne kawai a cikin yanayin a lokacin da aikin zai bayar da kuɗaɗen.

Don jira ko kada su jira?

Hakika, likitoci alkawari sauti m, amma a lokaci guda gaskiya hanyar shakka. Nawa lokaci Adam ke fama da ciwon daji, ta yaya mutane da yawa wadanda a wannan cuta ya kasance a baya 'yan shekarun da suka gabata, kuma a yanzu alkawari ba kawai wani tasiri magani, amma a ainihi da dama, - na kowane irin, a wani mataki. Amma yadda za a iya yi imani da shi? Kuma ko da muni - su yi ĩmãni ba, amma ba jira, kuma jira, amma dai itace cewa duk wajen ba kamar yadda mai kyau a matsayin sa ran, kamar yadda aka yi alkawari.

Ci gaban da miyagun ƙwayoyi - wata dabara kayyade aikin injiniya, cewa shi ne mafi m filin na magani a matsayin kimiyya. Wannan yana nufin cewa, tare da nasara saboda sakamakon da gaske ya zama da ban sha'awa. Duk da haka, a lokaci guda yana nufin cewa tsari ne musamman tsada. Matsayin mai mulkin, masu zuba jari suna son su zuba jari quite nauyi a cikin alamar ayyukan, amma idan batun kwayoyin halitta ne haka m, matsin lamba da yawa, amma lokacin da firam ne quite Heart, kasada an kiyasta yadda babbar. Yana yanzu sauti kaffa kintace ga 3-4 shekaru, amma kasuwar masana ne Masani game da yadda sau da yawa da lokaci zuwa ja jiki shekarun da suka gabata.

Abin mamaki, mai wuce yarda ... ko da yake da shi?

Fasahar binciken halittu - wani yanki rufe domin layman fahimta. Saboda haka, kawai bege na kalmar "nasara preclinical gwaji." Operating sunan miyagun ƙwayoyi samu wani "kadan buga gina jiki". Duk da haka, HSP - yana da kawai da babban bangaren na miyagun ƙwayoyi, ya yi alkawarin zama wani nasara a cikin kasuwar da kwayoyi da ciwon daji. Bayan shi, da abun da ke ciki ne kawai don hada ma lamba na gina jiki da za su tabbatar da tasiri na kudi. Kuma duk wannan ya yiwu saboda latest nazari HSP ya nuna cewa kwayoyin ba kawai taimaka kare da lalacewar rai Kwayoyin, amma kuma wani irin barã'aa "nuna yatsa" taimakawa wajen gano wanda Kwayoyin mamakin ƙari, da kuma wanda ba. Kawai sa, tare da bayyanar da jiki a isasshe babban taro na HSP, masana kimiyya fatan, na rigakafi da martani ta hanyar da kanta halakar da waxannan cututtukan abubuwa.

Fatan da kuma jira

Rungumar, zamu iya cewa da sabon anti-ƙari kahu a kan gaskiyar cewa jiki da kanta yana da wani kayan aiki da zai iya halakar da ƙari, kawai yanayin shi ne quite rauni. A maida hankali ne haka kananan cewa game da wani warkewa sakamako da kuma ba su da mafarki. A daidai wannan lokaci, wani ɓangare na HSP a Kwayoyin suna ba ta shafa ƙari, kuma daya kwayoyin ba zai "bar". Saboda haka, ake bukata bayarwa na daga cikin m wakili daga waje - cewa shi kara umarnin tasiri a shafi abubuwa. Ba zato ba tsammani, yayin da masana kimiyya imani da cewa ko da gefen sakamakon da miyagun ƙwayoyi ba zai yi - da kuma shi ne a irin wannan babban yi! Kuma bayyana wannan "sihiri" cewa karatu sun nuna - akwai wani yawan guba. Duk da haka, da karshe karshe za a yi a lokacin da pre-asibiti gwaji zo ga ƙarshe, wanda zai bukaci a kalla a shekara.