M myeloid cutar sankarar bargo

M cutar sankarar bargo - wata cuta daga cikin hematopoietic tsarin, dangane da - da Unlimited yaduwa na ƙari Kwayoyin, wanda suke ta morphological substrate. M myeloid cutar sankarar bargo a kan Fab rarrabuwa ne zuwa kashi bakwai zabin. Dalili na rarrabuwa - matakin bambantawa daga cikin sel wakiltar substrate cutar sankarar bargo. Myeloblasts ƙari clone aka samu daga kara Kwayoyin, wanda suke iya samar da mazauna girma yawan myeloid Kwayoyin, megakaryocytes, erythrocytes, macrophages.

A mafi akai-akai lura bambance-bambancen karatu M0-M3. Dalili na farko da biyu - Kwayoyin ba tare da bambance. differentsirovanokletochny - M2 zaɓi. M3 promyelocytic embodiment ne halin da mahaukaci Kwayoyin to giant hatsi. M4 da M5 - myeloblastic cutar sankarar bargo da kuma monoblastny. M6 - erythromyelosis, tare da ƙara yaduwa na erythroid Kwayoyin. M7 - megacaryoblastic cutar sankarar bargo. Daga cikin dukkan zabin, wanda aka gabatar tare da m myeloblastic cutar sankarar bargo, hangen nesa ne mafi m lokacin da M0-M2.

etiopathogenesis cutar sankarar bargo

Mene ne m myelogenous cutar sankarar bargo. A cuta - inganta ikon na sel maye gurbi saboda da mataki na waje dalilai (radiation, ƙwayoyin cuta, da sinadaran abubuwa) da kuma predisposition zuwa kayyade rashin zaman lafiya a genome. Wannan results a cikin ƙari Kwayoyin iya Unlimited division. Sai suka samar da wani clone wanda, bi da bi, da maimaita maye gurbi bada Yunƙurin zuwa subclones.

Ƙari Kwayoyin suna ci gaba da samar a cikin bargo, da kuma tilasta tareda žata al'ada jam hematopoiesis. A hankali, su je gefe jini da kuma metastasize zuwa gabobin, forming ƙarin foci na mahaukaci hematopoiesis. Developing myeloid cutar sankarar bargo tare da halayyar asibiti hoto a gare shi.

Clinic m myelogenous cutar sankarar bargo

Saboda rushewa daga cikin al'ada hematopoiesis a marasa lafiya tare da anemia, da yawan balagagge neutrophils da platelets rage-rage sharply. M juwa. rauni. Akwai alamun na jini: hemorrhages a cikin fata da kuma mucous membranes, ta ƙara zub da jini a lokacin haila, nosebleeds. Pain a cikin ƙasusuwansa, kumbura Lymph nodes na daban-daban kungiyoyin. Karuwan baƙin ciki, kuma hanta. Saboda cuta aiki na leukocytes, rage rigakafi m myeloblastic cutar sankarar bargo gudana Accession cututtuka. ya sau da yawa bayyana tsanani angina.

A baya, saukarwa iya a haɗe ãyõyin koda gazawar da kuma neurological bayyanar cututtuka.

A da ya kwarara m myeloblastic cutar sankarar bargo kara mataki tura bayyananen, gafarta musu, cutar ta koma dawowa. A cikin hali na m magani shi ƙare da m mataki. Stage da cutar halin da wasu na asibiti cututtuka da kuma jini hoto da kuma bargo.

ganewar asali daga cutar sankarar bargo

M myeloid cutar sankarar bargo da aka yi da cytochemical nazarin Kwayoyin wakiltar ta substrate da immunophenotyping - kayyade myeloid saka alama. Morphological hanyoyin domin ganewa na tsãwa Kwayoyin a kayyade da irin cutar sankarar bargo da aka bai wa wani nuni darajar, kuma kõ dã sun ci gaba da zuwa ji dadin.

Wani lokacin amfani genotypic hanyoyin dangane polymerase sarkar dauki. Ana amfani domin sanin saura manifestations da cutar a marasa lafiya a gafarta musu.

M myelogenous cutar sankarar bargo hangen nesa kasa m fiye da hangen nesa daga m lymphatic cutar sankarar bargo. Up to 75% na marasa lafiya da isassun magani cimma gafarta musu. Akwai shaida da na waraka daga 20% samu gafarar tare da ci gaba m magani. A karfafa sakamakon da aka samu ta hanyar bargo dasawa.