Antinociceptive mutum tsarin rage zafi

Antinociceptive tsarin na jikin mutum a fili delimited jijiya tsarin located a duk fannoni, kuma a dukkan sassa na tsakiya m tsarin. Su hade ne da wani irin matsayi na aiki neurochemical makamai, da ciwon da ikon dakatar da aiki m Tsarin cikin nociceptive tsarin.

Action antinociceptive tsarin

Lokacin da tsarin yana amfani antipain yawanci opiotergicheskaya gudãnar kewaye. Shi ne da hulda da opioid rabe da ligands-opioids. Shiga tsakani da antinociceptive tsarin iya kashe rashin jin daɗi numfashi ba abin mamaki a daban-daban matakan. Godiya ga aikin na inji na zafi da rashin jin daɗi ba zama marinjãya ji a rayuwar mutum. Ko lokacin da zafi ya zo, mukaddashin abubuwa antinociceptive tsarin suna kunshe a cikin aiki da cewa za ka iya ji a cikin lokacin da zafi mãsu bãyar da bãya, ɗan hutu. Wannan shi ne babban aikin wannan m inji a jikin kowane mutum.

Ma'ana na narcotic maganin ciwo a yau

Interest a narcotic kwayoyi, ta hanyar, kuma ta haifi antinociceptive tsarin. A Physiology na jikin mutum a fili kayyade manufar kwayoyi a magani: suna amfani da wani iko da m miyagun ƙwayoyi da cewa zai iya taimakawa wajen shawo kan da zafi antinociceptive tsarin ko yi ta canza.

Don kwanan wata, kwayoyi - kadai hanyar wani tasiri symptomatic magani na marasa lafiya da ciwon daji. Yana da quite yiwu ya baratar da amfani da miyagun ƙwayoyi, shan la'akari da analgesic sakamako. Duk da haka, duk san babban hasara na wadannan kwayoyi za su iya kunna isasshen, wajen tunani barga mutum a dogara da dabba fuskantar unearthly baƙin ciki, kuma mai yiwuwa ya ƙare aiki prematurely.

Bambance-bambance tsakanin nociceptive da antinociceptive tsarin

Antinociceptive tsarin ne determinant na zafi, wanda ya tabbatar da xari bisa dari zafi ji. Ganin wannan lokaci, bambanci tsakanin wannan manufar da Kalmar "azanci shine tsarin" za a iya bayyana sauƙi. Tun lokacin da ya karbi muhimman hakkokin "na'urar", t. E. Kamar wancan fassara analyzer iya kawai za a kira mai raba ɓaɓɓake daga haska tsarin, da nociceptive da antinociceptive tsarin cumulatively wakiltar ba kawai da determinant, kuma a kai somatic wajen rikitarwa tsarin.

Don gane da abin da wannan yana nufin, shi wajibi ne don ba da misali. Yi ya sani cikin rare lokuta na wani rashin jin zafi a cikin mutane, shi ne m. A halin yanzu, babban nociceptive hanyar da suka yi aiki kullum, watau. E. hana inji aiki zafi aiki.

Kamar yadda akwai zafi da wata azãba mai buga?

By da 70 ga watan shekara na karni na karshe, masu bincike sun karshe kafa wani ra'ayi game da wannan ɓangare na tsakiya m tsarin kamar yadda kwakwalwa antinociceptive tsarin. A wancan lokaci, masana kimiyya sun iya kafa ta gazawar zafi zumudi, overvoltage rigakafin Tsarin nociceptive sashen. Kara hangula nociceptive aiki braking tsarin tsokani wannan tsari antipain abubuwa.

Gunaguni da zafi na iya faruwa ne kawai idan karkashin matsananci effects a jiki antinociceptive tsarin ba za a iya suppressed saboda rinjayar extraneous dalilai. Rage birki aiki ne fraught tare da overexcitation nociceptive tsarin da kuma haddasa unforeseen m zafi na psychogenic halitta a cikin gaba daya na al'ada da ba-da waxannan cututtukan gabobin.

Analgesic tsarin na jiki tsarin

Idan akai la'akari da manufar antinociception (antinociceptive tsarin), ya kamata ka kula da ta mutum aka gyara. Daga gare su, na farko shi ne ya kamata a lura da abubuwa na dorsal midbrain da medulla (m al'amari, da tsakiya da reticular samuwar da raphe tsakiya, gelatinous bangaren na laka).

Godiya a gare su, akwai na asali tarewa zafi. Mutum daina jin zafi a lokacin da neman up nociceptive zumudi juyi amenable don hanawa. Wannan aiki nasa ne da sauko zafi iko. Babban aiki abubuwa a cikin braking aiki yi opioids da kuma wasu hormones, kamar serotonin. Daidai a kira su modulators saboda sun canza ainihin matsayin da guntun neurons, alhãli kuwa ba wucewa a su shugabanci wani m sakamako.

Neurotransmitters da rabe a zafi antitsitseptivnoy tsarin

Babban kuma predetermining neurons analgesic tsarin ne waɗanda located in m al'amari na midbrain. Muhimmiyar rawa a nan da kuma axons, wanda an tashi zuwa hypothalamus da sauran sunadaran na bar cerebral yammancin duniya. Sun kuma shiga a gaban shugabanci ga laka. Shiga tsakani da wadannan neurons aka dauke pentapeptides, wanda sun hada da enkephalins subspecies. Irin wannan shiga tsakani a cikin nau'i na amino acid dole ne samu methionine, kuma leucine.

Enkephalins ne iya a takaice in mun gwada lokaci, don fara duk na opiate rabe. Lokacin da opiatergicheskih synapses, wadannan rabe suna located, yafi a kan membrane, wanda daukawa fitar da ayyuka na postsynaptic "matashi". Ba shiga a cikin synapses zama m, yayin da membrane dole ne a kasaftawa shiga tsakani shiryar da m zumudi daga wani musamman neuron zuwa wani.

Na ciki antinociceptive tsarin yana da halayyar opioid rabe, da cewa suna da metabotropic. Suna sau da yawa dangantaka bioregulator haddasa hanawa na adenylate cyclase ta cikin kwayuka fitarwa. A sakamakon duk na sama ne tashin hankali a kira antipain tsarin. Bayan pathological rage na alli a cikin jikin mutum hada da babban shiga tsakani na jin zafi, t. E. The jiki fara samar da su a kan nasu. Mafi na kowa shiga tsakani na zafi ne:

• abu P.
• cholecystokinin.
• somatostatin.
• glutamic acid.

Hypothalamus da bar yammancin duniya na kwakwalwa - activators na mataki

By tsarin da tsarin sun hada da antipain analgesic hypothalamic Tsarin da somatosensory bawo na bar cerebral yammancin duniya. A immensity na hana ruwa guda sakamako a kan nociceptive sunadaran mutum aka samu ta hanyar:

• hanawa da nisa da tushe effects a kan neurons na laka.
• mafitar braking sakamako a kan neurons na thalamus.
• da kunna effects a kan muka ambata a sama tsarin na saman-saukar iko da birki.

Disengagement na jin zafi a cikin jiki

Nociceptive da antinociceptive tsarin na jiki ne a kusa da daidaituwa. A karshen samar na ciki opioid aka gyara, wanda a gaskiya ne mai magani a cikin.

Wadannan sun hada da endorphins, dynorphin, da sauransu. D. A peculiarity na da sinadaran abun da ke ciki ne m peptide jerin, kamar kankanin sunadarai na gina jiki da cewa an yi sama da amino acid.

Rawar da ba opioid da opioid peptides

A wani m yawan neurons da ya hada da antinociceptive tsarin musamman rabe located to irin wannan abubuwa. Alal misali, a lamba tare da opioid rabe sau da yawa bayyana a m braking aiki na mutum neurons. A wannan yanayin, nociceptive zafi tsarin zama hana da kuma zafi kusan ba ya amsa. The abu na kananan neurons analgesic tsarin ne toshewa na watsa da kuma rarraba zafi m zumudi sarkar endings.

A kullum aiwatar da fitowan da zafi ya shafi ba kawai opioid peptides. Non-opioid peptides (msl, neurotensin) kuma zai shafi karshe bolevospriyatie adam. Tasowa daga da dama kafofin, da zafi iya hana noradrenaline, dopamine, serotonin da kuma sauran catecholamines.

Ta yaya ginshikai na danniya da zafi?

Antinociceptive aiki na jiki tsarin zai iya zama hanyoyi da dama:

1. Ginshikai na gaggawa mataki. Akwai dauki mai raɗaɗi kara kuzari, haddasa synaptic zumudi a cikin tsarin na saukowa hana ruwa guda iko. A cikin raya Kakakin na laka a wannan lokacin za a iya gani iyakance afferent nociceptive ruri. A cikin babban ɓangare na analgesia wannan ginshiki. Lokacin da danniya na zafi lokaci guda aiki biyu m kara kuzari.
2. Ginshikai na mataki takaice. Fara da hypothalamus, a shafe birki kula da tsarin sauko irin dorsal midbrain da medulla. Don kunna inji for iyakance zumudi na jin zafi a matakin na kashin baya da kuma wani lokacin kwakwalwa da ake bukata stressors.
3. Ginshikai na dogon mataki. Babban cibiyoyin suna located in hypothalamus, aka kunna a akai zafi. Updraft m zumudi yana daukar kwayar cutar zuwa dukkan sassa na downward iko. By da nociceptive tsarin ta haɗu da wani tunanin saka launi na jin zafi. Irin wannan hakkin a mafi yawan lokuta ba haƙiƙa.
4. Tonic inji. Saboda ya m aiki antinociceptive tsarin goyan bayan cibiyoyin orbital da frontal yankunan da cerebral bawo. Suna located a cikin frontal lobe, bayan da idanu. Aiki nociceptive tsarin tabbatar da akai braking sakamako. Af, wannan tsari za a iya gani, da kuma cikakken babu zafi.

Mene ne zafi?

Antsinotsitseptivnaya tsarin na jiki, don sarrafa tsarin da cerebral bawo, na taimaka shirya domin pre-mugun jin sakamako, sa'an nan kai da kara kuzari na jin zafi tare da wani karu daga m, m majiyai.

Daga duk na sama, za ka iya zana wani sauki Tsayawa akan matsayin cewa da tsanani da kuma yanayi na zafi qaddara fasali na aiki na da tsari biyu: nociceptive da antinociceptive. Farko - cikin zafi, na biyu - antipain. A ƙayyadaddu na hulda da kayyade yanayin da zafi samu ta hanyar wani mutum. A zafi na iya zama daban-daban, kamar haka:

• Hyperalgesia - jihar a lokacin da ya karu ji na ƙwarai to zafi, saboda abin da abin da zai iya zama ko dai high agitation tsarin nociceptive ko antinociceptive low zumudi tsarin.
• Hypoalgesia - a jihar a wani rage ji na ƙwarai to zafi sakamakon daga m sakamako: zafi antinociceptive tsarin ya karu da kuma rage nociceptive tsarin zumudi.

Yanayin biyu za su iya samun wani tasiri a kan jiki, da kuma sun fi mayar dogara a kan dokin zafi. Wannan darajar wakiltar wani ba-tsaye m bangaren, zai bambanta da siffofin na zafi da analgesic tsarin. Kuma antinociceptive kuma samar da wata guda tsarin nociceptive zafi hadaddun, kasancewa kawai ta abubuwa.

Abin da ya razana su cutar da mutum?

Ã'a rikitarwa azanci shine bolevospriyatiya tsarin bukata domin mutum ya kula da jiki, da kuma sassa a cikin mutunci. Haka kuma, wadannan tsarin aiki cuta (zafi da antipain) shafar rayuwar mutum barnatar. A m short ko na kullum zafi majiyai, da wadannan na faruwa:

1. barci disturbances.
2. Rashin jima'i so.
3. Irritability, tsõro.
4. A karu a motor aiki.
5. Mawuyacin, tawayar Psycho-wani tunanin jihar.

Gunaguni da zafi - mutuwa

M zafi na iya rage numfashi, wani lokacin ma dakatar da shi gaba daya, yayin da wani rauni bango zafi zai iya shafar ta hanzari. A ciwo mai tsanani qara zuciya rate, ta ƙara jini, wanda barazana ga ci gaban gefe jijiyoyin bugun gini spasm.

Na farko, da fata ya zama kodadde, amma gajere zafi dilated jini sa flushing shi. Rage mugunya yau, na ciki da ruwan 'ya'yan itace da kuma samar da pancreas, hanji hanginsu Tashoshi, wanda sau da yawa take kaiwa zuwa anuria. A ci gaba mai raɗaɗi a buga a lokacin da ciwo mai tsanani ne fraught tare da m sakamakon.